The microtubule-dependent kinesin-like protein Eg5 from Homo sapiens is involved in the assembly of the mitotic spindle. It shows a three-domain structure with an N-terminal motor domain, a central coiled coil, and a C-terminal tail domain. In vivo HsEg5 is reversibly inhibited by monastrol, a small cell-permeable molecule that causes cells to be arrested in mitosis. Both monomeric and dimeric Eg5 constructs have been examined in order to define the minimal monastrol binding domain on HsEg5. NMR relaxation experiments show that monastrol interacts with all of the Eg5 constructs used in this study. Enzymatic techniques indicate that monastrol partially inhibits Eg5 ATPase activity by binding directly to the motor domain. The binding is nonco...
The kinesin Eg5 plays an essential role in bipolar spindle formation. A variety of structurally dive...
Small molecules that perturb specific protein functions are valuable tools for dissecting complex pr...
International audienceThe kinesin Eg5 plays an essential role in bipolar spindle formation. A variet...
The microtubule-dependent kinesin-like protein Eg5 from Homo sapiens is involved in the assembly of ...
ABSTRACT: The microtubule-dependent kinesin-like protein Eg5 from Homo sapiens is involved in the as...
AbstractMonastrol, a cell-permeable inhibitor of the kinesin Eg5, has been used to probe the dynamic...
Eg5 or KSP is a homotetrameric Kinesin-5 involved in centrosome separation and assembly of the bipol...
Controlled activity of several kinesin motors is required for the proper assembly of the mitotic spi...
Human Eg5, a mitotic motor of the kinesin superfamily, is involved in the formation and maintenance ...
Monastrol, a cell-permeable small molecule inhibitor of the mitotic kinesin, Eg5, arrests cells in m...
Drugs that target mitotic spindle proteins have been proven useful for tackling tumor growth. Eg5, a...
Cytoskeletal motor proteins utilize the energy from ATP turnover to perform work along their filamen...
ABSTRACT: Eg5 is a kinesin-like motor protein required for mitotic progression in higher eukaryotes....
The human mitotic kinesin HsEg5 plays an essential role in cell division. This protein is required f...
The mitotic kinesin Eg5 plays an essential role in establishing the bipolar spindle. Recently, sever...
The kinesin Eg5 plays an essential role in bipolar spindle formation. A variety of structurally dive...
Small molecules that perturb specific protein functions are valuable tools for dissecting complex pr...
International audienceThe kinesin Eg5 plays an essential role in bipolar spindle formation. A variet...
The microtubule-dependent kinesin-like protein Eg5 from Homo sapiens is involved in the assembly of ...
ABSTRACT: The microtubule-dependent kinesin-like protein Eg5 from Homo sapiens is involved in the as...
AbstractMonastrol, a cell-permeable inhibitor of the kinesin Eg5, has been used to probe the dynamic...
Eg5 or KSP is a homotetrameric Kinesin-5 involved in centrosome separation and assembly of the bipol...
Controlled activity of several kinesin motors is required for the proper assembly of the mitotic spi...
Human Eg5, a mitotic motor of the kinesin superfamily, is involved in the formation and maintenance ...
Monastrol, a cell-permeable small molecule inhibitor of the mitotic kinesin, Eg5, arrests cells in m...
Drugs that target mitotic spindle proteins have been proven useful for tackling tumor growth. Eg5, a...
Cytoskeletal motor proteins utilize the energy from ATP turnover to perform work along their filamen...
ABSTRACT: Eg5 is a kinesin-like motor protein required for mitotic progression in higher eukaryotes....
The human mitotic kinesin HsEg5 plays an essential role in cell division. This protein is required f...
The mitotic kinesin Eg5 plays an essential role in establishing the bipolar spindle. Recently, sever...
The kinesin Eg5 plays an essential role in bipolar spindle formation. A variety of structurally dive...
Small molecules that perturb specific protein functions are valuable tools for dissecting complex pr...
International audienceThe kinesin Eg5 plays an essential role in bipolar spindle formation. A variet...