348— Establishment of peptide aggregation process

The adsorption of alpha-synuclein (a-syn) was studied by attempting the adsorption over the surface of nano-gold colloidal particles as a function of concentration of the a-syn. The change in surface property caused by the degree of peptide coverage was hypothesized to reflect the aggregation formation channels. As the concentration of the a-syn increased, the aggregation size had increased in a non-linear fashion. Currently, we hypothesize two different aggregation channels and one is a gradual growth and the other is a step function type of behavior which holds a certain threshold to form an aggregate