Studies on Delayed-Type Hypersensitivity Including Attempts to Effect Transfer in Guinea Pigs with Subcellular Materials

The initial observation that delayed-type hypersensitivity could be transferred from an allergic to a normal animal by means of living white cells was made at The Rockefeller Institute many years ago. Since that time it has been recognized that cellular transfer appears to be a unifying principle underlying both contact dermatitis and tuberculin hypersensitivity. Later studies in man have suggested that the phenomenon can be reproduced with use cell-free extracts. Similar attempts have been made with extracts of cells from sensitized guinea pigs but, there exist only three reports in the literature which claim that transfer of contact or tuberculin hypersensitivity can be readily accomplished between animals (guinea pigs) by means of disrupted cells or subcellular materials