A peptidase-resistant ABL kinase substrate was developed by identifying protease-susceptible bonds on an ABL substrate peptide and replacing flanking amino acids with non-native amino acids
AbstractThe Bcr-Abl fusion protein kinase causes chronic myeloid leukemia and is targeted by the sig...
11noThe pathogenic role of the overactivated ABL1 tyrosine kinase (TK) pathway is well recognized in...
Imatinib mesylate is a potent inhibitor of Bcr-Abl tyrosine kinase, an oncoprotein that plays a key ...
Synthetic peptides are widely used by the biomedical research community as kinase substrates for pur...
A strategy was developed to extend the lifetime of an peptide-based substrate for Abl kinase in the ...
Protein kinases (PKs) are an important class of enzymes that control critical cellular processes and...
The constitutively active tyrosine kinase BCR-ABL is the underlying cause of chronic myeloid leukemi...
Chronic myelogenous leukemia (CML) is a myeloproliferative disorder that is characterized by massive...
Imatinib mesylate is a potent inhibitor of Bcr-Abl tyrosine kinase, an oncoprotein that plays a key ...
An iterative design strategy using three criteria was utilized to develop a peptidase-resistant subs...
The stability of an Abl kinase substrate peptide in a cytosolic lysate and in single cells was chara...
The BCR/ABL fusion protein is the hallmark of Philadelphia Chromosome positive (Ph+) leukemia. The c...
As discussed in chapter 1, phosphorylation is a very important post-translational modification in si...
<b>Objective:</b> The recent success in treating chronic myeloid leukemia (CML) with tyr...
As discussed in chapter 1, phosphorylation is a very important post-translational modification in si...
AbstractThe Bcr-Abl fusion protein kinase causes chronic myeloid leukemia and is targeted by the sig...
11noThe pathogenic role of the overactivated ABL1 tyrosine kinase (TK) pathway is well recognized in...
Imatinib mesylate is a potent inhibitor of Bcr-Abl tyrosine kinase, an oncoprotein that plays a key ...
Synthetic peptides are widely used by the biomedical research community as kinase substrates for pur...
A strategy was developed to extend the lifetime of an peptide-based substrate for Abl kinase in the ...
Protein kinases (PKs) are an important class of enzymes that control critical cellular processes and...
The constitutively active tyrosine kinase BCR-ABL is the underlying cause of chronic myeloid leukemi...
Chronic myelogenous leukemia (CML) is a myeloproliferative disorder that is characterized by massive...
Imatinib mesylate is a potent inhibitor of Bcr-Abl tyrosine kinase, an oncoprotein that plays a key ...
An iterative design strategy using three criteria was utilized to develop a peptidase-resistant subs...
The stability of an Abl kinase substrate peptide in a cytosolic lysate and in single cells was chara...
The BCR/ABL fusion protein is the hallmark of Philadelphia Chromosome positive (Ph+) leukemia. The c...
As discussed in chapter 1, phosphorylation is a very important post-translational modification in si...
<b>Objective:</b> The recent success in treating chronic myeloid leukemia (CML) with tyr...
As discussed in chapter 1, phosphorylation is a very important post-translational modification in si...
AbstractThe Bcr-Abl fusion protein kinase causes chronic myeloid leukemia and is targeted by the sig...
11noThe pathogenic role of the overactivated ABL1 tyrosine kinase (TK) pathway is well recognized in...
Imatinib mesylate is a potent inhibitor of Bcr-Abl tyrosine kinase, an oncoprotein that plays a key ...
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