Core pathway mutations induce de-differentiation of murine astrocytes into glioblastoma stem cells that are sensitive to radiation but resistant to temozolomide
- Schmid, Ralf S.
- Simon, Jeremy M.
- Vitucci, Mark
- McNeill, Robert S.
- Bash, Ryan E.
- Werneke, Andrea M.
- Huey, Lauren
- White, Kristen K.
- Ewend, Matthew G.
- Wu, Jing
- Miller, C. Ryan
DOIAbstract
Glioma stem cells (GSCs) from human glioblastomas (GBMs) are resistant to radiation and chemotherapy and may drive recurrence. Treatment efficacy may depend on GSCs, expression of DNA repair enzymes such as methylguanine methyltransferase (MGMT), or transcriptome subtype
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