Inhaled alpha1-proteinase inhibitor (PI) is known to reduce neutrophil elastase burden in some patients with CF. This phase 2a study was designed to test inhaled Alpha-1 HC, a new aerosolized alpha1-PI formulation, in CF patients
RATIONALE:In cystic fibrosis (CF) a reduction in airway surface liquid (ASL) height compromises muco...
BACKGROUND: The chemokine interleukin-8 (CXCL8) is a key mediator of inflammation in airways of pati...
Cystic fibrosis (CF) is a multisystem disorder with significantly shortened life expectancy. The maj...
Summary. Neutrophil elastase (NE) is thought to be themost important proteasewhich damages the cysti...
The airways of cystic fibrosis (CF) patients are characterised by neutrophils that release high amou...
BACKGROUND: MRT5005, a codon-optimized CFTR mRNA, delivered by aerosol in lipid nanoparticles, was d...
ABSTRACT: Cystic fibrosis (CF) is characterised by inspissated airway secretions and chronic endobro...
Copyright © 2016 by the American Thoracic Society. Neutrophil elastase (NE) activity is associated w...
Rationale: Glutathione is the major antioxidant in the extracellular lining fluid of the lungs and d...
he contribution of the neutrophil-derived serine pro-tease neutrophil elastase (NE) to lung disease ...
Background: Inhibition of the epithelial sodium channel (ENaC) in cystic fibrosis (CF) airways provi...
Background Neutrophil elastase (NE) has been linked to lung neutrophil dysfunction in bronchiectasis...
AbstractBackground: A pilot evaluation to assess the safety and possible benefits of TLC C-53, (pros...
In CF patients, Glutathione (GSH), the first-line defence of lungs against oxidative stress, is seve...
AbstractBackgroundIt is hypothesized that a CXCR2 receptor antagonist would inhibit the recruitment ...
RATIONALE:In cystic fibrosis (CF) a reduction in airway surface liquid (ASL) height compromises muco...
BACKGROUND: The chemokine interleukin-8 (CXCL8) is a key mediator of inflammation in airways of pati...
Cystic fibrosis (CF) is a multisystem disorder with significantly shortened life expectancy. The maj...
Summary. Neutrophil elastase (NE) is thought to be themost important proteasewhich damages the cysti...
The airways of cystic fibrosis (CF) patients are characterised by neutrophils that release high amou...
BACKGROUND: MRT5005, a codon-optimized CFTR mRNA, delivered by aerosol in lipid nanoparticles, was d...
ABSTRACT: Cystic fibrosis (CF) is characterised by inspissated airway secretions and chronic endobro...
Copyright © 2016 by the American Thoracic Society. Neutrophil elastase (NE) activity is associated w...
Rationale: Glutathione is the major antioxidant in the extracellular lining fluid of the lungs and d...
he contribution of the neutrophil-derived serine pro-tease neutrophil elastase (NE) to lung disease ...
Background: Inhibition of the epithelial sodium channel (ENaC) in cystic fibrosis (CF) airways provi...
Background Neutrophil elastase (NE) has been linked to lung neutrophil dysfunction in bronchiectasis...
AbstractBackground: A pilot evaluation to assess the safety and possible benefits of TLC C-53, (pros...
In CF patients, Glutathione (GSH), the first-line defence of lungs against oxidative stress, is seve...
AbstractBackgroundIt is hypothesized that a CXCR2 receptor antagonist would inhibit the recruitment ...
RATIONALE:In cystic fibrosis (CF) a reduction in airway surface liquid (ASL) height compromises muco...
BACKGROUND: The chemokine interleukin-8 (CXCL8) is a key mediator of inflammation in airways of pati...
Cystic fibrosis (CF) is a multisystem disorder with significantly shortened life expectancy. The maj...
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