Evaluation of Serologic and Antigenic Relationships Between Middle Eastern Respiratory Syndrome Coronavirus and Other Coronaviruses to Develop Vaccine Platforms for the Rapid Response to Emerging Coronaviruses
- Sudhakar Agnihothram
- Robin Gopal
- Boyd L. Yount Jr
- Eric F. Donaldson
- Vineet D. Menachery
- Rachel L. Graham
- Trevor D. Scobey
- Lisa E. Gralinski
- Mark R. Denison
- Maria Zambon
- Ralph S. Baric
DOIAbstract
Background. Middle East respiratory syndrome coronavirus (MERS-CoV) emerged in 2012, causing severe acute respiratory disease and pneumonia, with 44% mortality among 136 cases to date. Design of vaccines to limit the virus spread or diagnostic tests to track newly emerging strains requires knowledge of antigenic and serologic relationships between MERS-CoV and other CoVs
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