A semiquantitative metric for evaluating clinical actionability of incidental or secondary findings from genome-scale sequencing
- Berg, Jonathan S.
- Foreman, Ann Katherine M.
- O'Daniel, Julianne M.
- Booker, Jessica K.
- Boshe, Lacey
- Carey, Timothy
- Crooks, Kristy R.
- Jensen, Brian C.
- Juengst, Eric T.
- Lee, Kristy
- Nelson, Daniel K.
- Powell, Bradford C.
- Powell, Cynthia M.
- Roche, Myra I.
- Skrzynia, Cecile
- Strande, Natasha T.
- Weck, Karen E.
- Wilhelmsen, Kirk C.
- Evans, James P.
DOIAbstract
As genome-scale sequencing is increasingly applied in clinical scenarios, a wide variety of genomic findings will be discovered as secondary or incidental findings, and there is debate about how they should be handled. The clinical actionability of such findings varies, necessitating standardized frameworks for a priori decision making about their analysis
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