Comprehensive and Integrated Genomic Characterization of Adult Soft Tissue Sarcomas
- Abeshouse, Adam
- Adebamowo, Clement
- Adebamowo, Sally N.
- Akbani, Rehan
- Akeredolu, Teniola
- Ally, Adrian
- Anderson, Matthew L.
- Anur, Pavana
- Appelbaum, Elizabeth L.
- Armenia, Joshua
- Auman, J. Todd
- Bailey, Matthew H.
- Baker, Laurence
- Balasundaram, Miruna
- Balu, Saianand
- Barthel, Floris P.
- Bartlett, John
- Baylin, Stephen B.
- Behera, Madhusmita
- Belyaev, Dmitry
- Bennett, Joesph
- Benz, Christopher
- Beroukhim, Rameen
- Birrer, Michael
- Bocklage, Thèrése
- Bodenheimer, Tom
- Boice, Lori
- Bootwalla, Moiz S.
- Bowen, Jay
- Bowlby, Reanne
- Boyd, Jeff
- Brohl, Andrew S.
- Brooks, Denise
- Byers, Lauren
- Carlsen, Rebecca
- Castro, Patricia
- Chen, Hsiao-Wei
- Cherniack, Andrew D.
- Chibon, Fréderic
- Chin, Lynda
- Cho, Juok
- Chuah, Eric
- Chudamani, Sudha
- Cibulskis, Carrie
- Cooper, Lee A.D.
- Cope, Leslie
- Cordes, Matthew G.
- Crain, Daniel
- Curley, Erin
- Danilova, Ludmila
- Dao, Fanny
- Davis, Ian J.
- Davis, Lara E.
- Defreitas, Timothy
- Delman, Keith
- Demchok, John A.
- Demetri, George D.
- Demicco, Elizabeth G.
- Dhalla, Noreen
- Diao, Lixia
- Ding, Li
- DiSaia, Phil
- Dottino, Peter
- Doyle, Leona A.
- Drill, Esther
- Dubina, Michael
- Eschbacher, Jennifer
- Fedosenko, Konstantin
- Felau, Ina
- Ferguson, Martin L.
- Frazer, Scott
- Fronick, Catrina C.
- Fulidou, Victoria
- Fulton, Lucinda A.
- Fulton, Robert S.
- Gabriel, Stacey B.
- Gao, Jianjiong
- Gao, Qingsong
- Gardner, Johanna
- Gastier-Foster, Julie M.
- Gay, Carl M.
- Gehlenborg, Nils
- Gerken, Mark
- Getz, Gad
- Godwin, Andrew K.
- Godwin, Eryn M.
- Gordienko, Elena
- Grilley-Olson, Juneko E.
- Gutman, David A.
- Gutmann, David H.
- Hayes, D. Neil
- Hegde, Apurva M.
- Heiman, David I.
- Heins, Zachary
- Helsel, Carmen
- Hepperla, Austin J.
- Higgins, Kelly
- Hoadley, Katherine A.
- Hobensack, Shital
- Holt, Robert A.
- Hoon, Dave B.
- Hornick, Jason L.
- Hoyle, Alan P.
- Hu, Xin
- Huang, Mei
- Hutter, Carolyn M.
- Iacocca, Mary
- Ingram, Davis R.
- Ittmann, Michael
- Iype, Lisa
- Jefferys, Stuart R.
- Jones, Kevin B.
- Jones, Corbin D.
- Jones, Steven J.M.
- Kalir, Tamara
- Karlan, Beth Y.
- Karseladze, Apollon
- Kasaian, Katayoon
- Kim, Jaegil
- Kundra, Ritika
- Kuo, Hanluen
- Ladanyi, Marc
- Lai, Phillip H.
- Laird, Peter W.
- Larsson, Erik
- Lawrence, Michael S.
- Lazar, Alexander J.
- Lee, Sanghoon
- Lee, Darlene
- Lehmann, Kjong-Van
- Leraas, Kristen M.
- Lester, Jenny
- Levine, Douglas A.
- Li, Irene
- Lichtenberg, Tara M.
- Lin, Pei
- Liu, Jia
- Liu, Wenbin
- Liu, Eric Minwei
- Lolla, Laxmi
- Lu, Yiling
- Ma, Yussanne
- Madan, Rashna
- Maglinte, Dennis T.
- Magliocco, Anthony
- Maki, Robert G.
- Mallery, David
- Manikhas, Georgy
- Mardis, Elaine R.
- Mariamidze, Armaz
- Marra, Marco A.
- Martignetti, John A.
- Martinez, Cathleen
- Mayo, Michael
- McLellan, Michael D.
- Meier, Sam
- Meng, Shaowu
- Meyerson, Matthew
- Mieczkowski, Piotr A.
- Miller, Christopher A.
- Mills, Gordon B.
- Moore, Richard A.
- Morris, Scott
- Mose, Lisle E.
- Mozgovoy, Evgeny
- Mungall, Andrew J.
- Mungall, Karen
- Nalisnik, Michael
- Naresh, Rashi
- Newton, Yulia
- Noble, Michael S.
- Novak, Janet E.
- Ochoa, Angelica
- Olvera, Narciso
- Owonikoko, Taofeek K.
- Paklina, Oxana
- Parfitt, Jeremy
- Parker, Joel S.
- Pastore, Alessandro
- Paulauskis, Joseph
- Penny, Robert
- Pereira, Elena
- Perou, Charles M.
- Perou, Amy H.
- Pihl, Todd
- Pollock, Raphael E.
- Potapova, Olga
- Radenbaugh, Amie J.
- Ramalingam, Suresh S.
- Ramirez, Nilsa C.
- Rathmell, W. Kimryn
- Raut, Chandrajit P.
- Riedel, Richard F.
- Reilly, Colleen
- Reynolds, Sheila M.
- Roach, Jeffrey
- Robertson, A. Gordon
- Roszik, Jason
- Rubin, Brian P.
- Sadeghi, Sara
- Saksena, Gordon
- Salner, Andrew
- Sanchez-Vega, Francisco
- Sander, Chris
- Schein, Jacqueline E.
- Schmidt, Heather K.
- Schultz, Nikolaus
- Schumacher, Steven E.
- Sekhon, Harman
- Senbabaoglu, Yasin
- Setdikova, Galiya
- Shelton, Candace
- Shelton, Troy
- Shen, Ronglai
- Shi, Yan
- Shih, Juliann
- Shmulevich, Ilya
- Sica, Gabriel L.
- Simons, Janae V.
- Singer, Samuel
- Sipahimalani, Payal
- Skelly, Tara
- Socci, Nicholas
- Sofia, Heidi J.
- Soloway, Matthew G.
- Spellman, Paul
- Sun, Qiang
- Swanson, Patricia
- Tam, Angela
- Tan, Donghui
- Tarnuzzer, Roy
- Thiessen, Nina
- Thompson, Eric
- Thorne, Leigh B.
- Tong, Pan
- Torres, Keila E.
- van de Rijn, Matt
- Van Den Berg, David J.
- Van Tine, Brian A.
- Veluvolu, Umadevi
- Verhaak, Roel
- Voet, Doug
- Voronina, Olga
- Wan, Yunhu
- Wang, Zhining
- Wang, Jing
- Weinstein, John N.
- Weisenberger, Daniel J.
- Wilkerson, Matthew D.
- Wilson, Richard K.
- Wise, Lisa
- Wong, Tina
- Wong, Winghing
- Wrangle, John
- Wu, Ye
- Wyczalkowski, Matthew
- Yang, Liming
- Yau, Christina
- Yellapantula, Venkata
- Zenklusen, Jean C.
- Zhang, Jiashan (Julia)
- Zhang, Hailei
- Zhang, Hongxin
- Zmuda, Erik
DOIAbstract
Sarcomas are a broad family of mesenchymal malignancies exhibiting remarkable histologic diversity. We describe the multi-platform molecular landscape of 206 adult soft tissue sarcomas representing 6 major types. Along with novel insights into the biology of individual sarcoma types, we report three overarching findings: (1) unlike most epithelial malignancies, these sarcomas (excepting synovial sarcoma) are characterized predominantly by copy-number changes, with low mutational loads and only a few genes (, , ) highly recurrently mutated across sarcoma types; (2) within sarcoma types, genomic and regulomic diversity of driver pathways defines molecular subtypes associated with patient outcome; and (3) the immune microenvironment, inferred ...
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