Effects of Mesenchymal Stem Cell and Growth Factor Delivery on Cartilage Repair in a Mini-Pig Model
- Fisher, Matthew B.
- Belkin, Nicole S.
- Milby, Andrew H.
- Henning, Elizabeth A.
- Söegaard, Nicole
- Kim, Minwook
- Pfeifer, Christian
- Saxena, Vishal
- Dodge, George R.
- Burdick, Jason A.
- Schaer, Thomas P.
- Steinberg, David R.
- Mauck, Robert L.
DOIAbstract
We have recently shown that mesenchymal stem cells (MSCs) embedded in a hyaluronic acid (HA) hydrogel and exposed to chondrogenic factors (transforming growth factor–β3 [TGF-β3]) produce a cartilage-like tissue in vitro. The current objective was to determine if these same factors could be combined immediately prior to implantation to induce a superior healing response in vivo relative to the hydrogel alone
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