Morphogenesis requires dynamic coordination between cell–cell adhesion and the cytoskeleton to allow cells to change shape and move without losing tissue integrity. We used genetic tools and superresolution microscopy in a simple model epithelial cell line to define how the molecular architecture of cell–cell zonula adherens (ZA) is modified in response to elevated contractility, and how these cells maintain tissue integrity. We previously found that depleting zonula occludens 1 (ZO-1) family proteins in MDCK cells induces a highly organized contractile actomyosin array at the ZA. We find that ZO knockdown elevates contractility via a Shroom3/Rho-associated, coiled-coil containing protein kinase (ROCK) pathway. Our data suggest that each bi...
The formation of a barrier between epithelial cells is a fundamental determinant of cellular homeost...
The formation of a barrier between epithelial cells is a fundamental determinant of cellular homeost...
One of the most common cell shape changes driving morphogenesis in diverse animals is the constricti...
Morphogenesis requires dynamic coordination between cell-cell adhesion and the cytoskeleton to allow...
ETOC: Our study reveals that ZO proteins in fully polarized cells regulate the assembly and contract...
ETOC: Our study reveals that ZO proteins in fully polarized cells regulate the assembly and contract...
During embryonic development, dramatic cell shape changes and movements reshape the embryonic body p...
SummaryBackgroundActomyosin-based contractility acts on cadherin junctions to support tissue integri...
The integrity of the tight junction barrier in epithelial and endothelial cells is critical to human...
Formation and maintenance of tissue barriers require the coordination of cell mechanics and cell–cel...
Coordination of adhesion and the actin cytoskeleton is critical in morphogenesis. Drosophila germban...
Fundamental processes in cell adhesion, motility, and rigidity adaptation are regulated by integrin-...
The integrity of the tight junction barrier in epithelial and endothelial cells is critical to human...
The zonula adherens (ZA) of epithelial cells is a site of cell-cell adhesion where cellular forces a...
AbstractCohesive sheets of epithelial cells are a fundamental feature of multicellular organisms and...
The formation of a barrier between epithelial cells is a fundamental determinant of cellular homeost...
The formation of a barrier between epithelial cells is a fundamental determinant of cellular homeost...
One of the most common cell shape changes driving morphogenesis in diverse animals is the constricti...
Morphogenesis requires dynamic coordination between cell-cell adhesion and the cytoskeleton to allow...
ETOC: Our study reveals that ZO proteins in fully polarized cells regulate the assembly and contract...
ETOC: Our study reveals that ZO proteins in fully polarized cells regulate the assembly and contract...
During embryonic development, dramatic cell shape changes and movements reshape the embryonic body p...
SummaryBackgroundActomyosin-based contractility acts on cadherin junctions to support tissue integri...
The integrity of the tight junction barrier in epithelial and endothelial cells is critical to human...
Formation and maintenance of tissue barriers require the coordination of cell mechanics and cell–cel...
Coordination of adhesion and the actin cytoskeleton is critical in morphogenesis. Drosophila germban...
Fundamental processes in cell adhesion, motility, and rigidity adaptation are regulated by integrin-...
The integrity of the tight junction barrier in epithelial and endothelial cells is critical to human...
The zonula adherens (ZA) of epithelial cells is a site of cell-cell adhesion where cellular forces a...
AbstractCohesive sheets of epithelial cells are a fundamental feature of multicellular organisms and...
The formation of a barrier between epithelial cells is a fundamental determinant of cellular homeost...
The formation of a barrier between epithelial cells is a fundamental determinant of cellular homeost...
One of the most common cell shape changes driving morphogenesis in diverse animals is the constricti...