Exposure to the agricultural fungicide vinclozolin during gestation promotes a higher incidence of various diseases in the subsequent unexposed F3 and F4 generations. This phenomenon is termed epigenetic transgenerational inheritance and has been shown to in part involve alterations in DNA methylation, but the role of other epigenetic mechanisms remains unknown. The current study investigated the alterations in small noncoding RNA (sncRNA) in the sperm from F3 generation control and vinclozolin lineage rats. Over 200 differentially expressed sncRNAs were identified and the tRNA-derived sncRNAs, namely 5' halves of mature tRNAs (5' halves), displayed the most dramatic changes. Gene targets of the altered miRNAs and tRNA 5' halves revealed as...
Epigenetics is defined as genomic modifications that alter gene expression without changing the nucl...
Advanced paternal age at fertilization is a risk factor for multiple disorders in offspring and may ...
AbstractEmbryonic exposure to the endocrine disruptor vinclozolin during gonadal sex determination a...
A number of environmental factors from nutrition to toxicants have been shown to promote the epigene...
Exposure to vinclozolin has been shown to induce the epigenetic transgenerational inheritance of inc...
Exposure to vinclozolin has been shown to induce the epigenetic transgenerational inheritance of inc...
Previous observations have demonstrated that embryonic exposure to the endocrine disruptor vinclozol...
19 p.-6 fig.In mammals, germ cell differentiation is initiated in the Primordial Germ Cells (PGCs) d...
In mammals, germ cell differentiation is initiated in the Primordial Germ Cells (PGCs) during fetal ...
<div><p>In mammals, germ cell differentiation is initiated in the Primordial Germ Cells (PGCs) durin...
Environmental toxicants have been shown to induce the epigenetic transgenerational inheritance of ad...
<div><p>Environmental toxicants have been shown to induce the epigenetic transgenerational inheritan...
Primordial germ cells (PGCs) are the embryonic precursors of the germ cell linage, which are restric...
Environmental toxicants such as DDT have been shown to induce the epigenetic transgenerational inher...
A number of environmental factors (e.g. toxicants) have been shown to promote the epigenetic transge...
Epigenetics is defined as genomic modifications that alter gene expression without changing the nucl...
Advanced paternal age at fertilization is a risk factor for multiple disorders in offspring and may ...
AbstractEmbryonic exposure to the endocrine disruptor vinclozolin during gonadal sex determination a...
A number of environmental factors from nutrition to toxicants have been shown to promote the epigene...
Exposure to vinclozolin has been shown to induce the epigenetic transgenerational inheritance of inc...
Exposure to vinclozolin has been shown to induce the epigenetic transgenerational inheritance of inc...
Previous observations have demonstrated that embryonic exposure to the endocrine disruptor vinclozol...
19 p.-6 fig.In mammals, germ cell differentiation is initiated in the Primordial Germ Cells (PGCs) d...
In mammals, germ cell differentiation is initiated in the Primordial Germ Cells (PGCs) during fetal ...
<div><p>In mammals, germ cell differentiation is initiated in the Primordial Germ Cells (PGCs) durin...
Environmental toxicants have been shown to induce the epigenetic transgenerational inheritance of ad...
<div><p>Environmental toxicants have been shown to induce the epigenetic transgenerational inheritan...
Primordial germ cells (PGCs) are the embryonic precursors of the germ cell linage, which are restric...
Environmental toxicants such as DDT have been shown to induce the epigenetic transgenerational inher...
A number of environmental factors (e.g. toxicants) have been shown to promote the epigenetic transge...
Epigenetics is defined as genomic modifications that alter gene expression without changing the nucl...
Advanced paternal age at fertilization is a risk factor for multiple disorders in offspring and may ...
AbstractEmbryonic exposure to the endocrine disruptor vinclozolin during gonadal sex determination a...