Glycosphingolipids are important constituents of cellular membranes. Glucosylceramide (GlcCer) is the simplest glycosphingolipid and serves as a building block for the synthesis of higher-order glycosphingolipids. Defects in the lysosomal beta-glucosidase 1 (GBA1), which cleaves GlcCer to glucose and ceramide, causes accumulation of GlcCer in lysosomes and, thereby, the severe lipid-storage disorder Gaucher disease. Knockout-mice lacking the non lysosomal beta glucosidase 2 (GBA2) accumulate GlcCer outside the lysosomes, resulting in globozoospermia – a severe male fertility defect. The molecular mechanisms underlying this fertility defect are unknown. In my PhD thesis, I (1) investigated the subcellular localization of GBA2 and (2) analyze...
GBA1 and GBA2 are both beta-glucosidases, which cleave glucosylceramide (GlcCer) to glucose and cera...
The classical recessive mouse mutant, bthe twitcher,Q is one of the several animal models of the hum...
Glucosylceramide (GlcCer) is one of the simplest glycosphingolipids (GSLs) synthesized at the cytoso...
Glycosphingolipids are important constituents of cellular membranes. Glucosylceramide (GlcCer) is th...
Glycosphingolipids are key elements of cellular membranes, thereby, controlling a variety of cellula...
<div><p>Glycosphingolipids are key elements of cellular membranes, thereby, controlling a variety of...
Glycosphingolipids are key elements of cellular membranes, thereby, controlling a variety of cellula...
<title>Author Summary</title> <p>During mammalian spermatogenesis, sperm with a head and a tail are ...
The membrane lipid glucosylceramide (GlcCer) is continuously formed and degraded. Cells express tw...
Glycosphingolipids (GSLs) are a large and heterogeneous class of lipids, whose function is equally v...
GBA1 and GBA2 are both beta-glucosidases, which cleave glucosylceramide (GlcCer) to glucose and cera...
GBA1 and GBA2 are both beta-glucosidases, which cleave glucosylceramide (GlcCer) to glucose and cera...
The classical recessive mouse mutant, bthe twitcher,Q is one of the several animal models of the hum...
One of the hallmarks of male germ cell development is the formation of a specialized secretory organ...
The classical recessive mouse mutant, bthe twitcher,Q is one of the several animal models of the hum...
GBA1 and GBA2 are both beta-glucosidases, which cleave glucosylceramide (GlcCer) to glucose and cera...
The classical recessive mouse mutant, bthe twitcher,Q is one of the several animal models of the hum...
Glucosylceramide (GlcCer) is one of the simplest glycosphingolipids (GSLs) synthesized at the cytoso...
Glycosphingolipids are important constituents of cellular membranes. Glucosylceramide (GlcCer) is th...
Glycosphingolipids are key elements of cellular membranes, thereby, controlling a variety of cellula...
<div><p>Glycosphingolipids are key elements of cellular membranes, thereby, controlling a variety of...
Glycosphingolipids are key elements of cellular membranes, thereby, controlling a variety of cellula...
<title>Author Summary</title> <p>During mammalian spermatogenesis, sperm with a head and a tail are ...
The membrane lipid glucosylceramide (GlcCer) is continuously formed and degraded. Cells express tw...
Glycosphingolipids (GSLs) are a large and heterogeneous class of lipids, whose function is equally v...
GBA1 and GBA2 are both beta-glucosidases, which cleave glucosylceramide (GlcCer) to glucose and cera...
GBA1 and GBA2 are both beta-glucosidases, which cleave glucosylceramide (GlcCer) to glucose and cera...
The classical recessive mouse mutant, bthe twitcher,Q is one of the several animal models of the hum...
One of the hallmarks of male germ cell development is the formation of a specialized secretory organ...
The classical recessive mouse mutant, bthe twitcher,Q is one of the several animal models of the hum...
GBA1 and GBA2 are both beta-glucosidases, which cleave glucosylceramide (GlcCer) to glucose and cera...
The classical recessive mouse mutant, bthe twitcher,Q is one of the several animal models of the hum...
Glucosylceramide (GlcCer) is one of the simplest glycosphingolipids (GSLs) synthesized at the cytoso...