A comprehensive and comparative phenotypic analysis of the collaborative founder strains identifies new and known phenotypes.
- Kollmus, H.
- Fuchs, H.
- Lengger, C.
- Haselimashhadi, H.
- Bogue, M.A.
- Östereicher, M.A.
- Horsch, M.
- Adler, T.
- Aguilar-Pimentel, J.A.
- Amarie, O.V.
- Becker, L.
- Beckers, J.
- Calzada-Wack, J.
- Garrett, L.
- Hans, W.
- Hölter, S.M.
- Klein-Rodewald, T.
- Maier, H.
- Mayer-Kuckuk, P.
- Miller, G.
- Moreth, K.
- Neff, F.
- Rathkolb, B.
- Rácz, I.
- Rozman, J.
- Spielmann, N.
- Treise, I.
- Busch, D.H.
- Graw, J.
- Klopstock, T.
- Wolf, E.
- Wurst, W.
- Yildirim, A.Ö.
- Mason, J.
- Torres, A.
- Balling, R.
- Mehaan, T.
- Gailus-Durner, V.
- Schughart, K.
- Hrabě de Angelis, M.
DOIAbstract
The collaborative cross (CC) is a large panel of mouse-inbred lines derived from eight founder strains (NOD/ShiLtJ, NZO/HILtJ, A/J, C57BL/6J, 129S1/SvImJ, CAST/EiJ, PWK/PhJ, and WSB/EiJ). Here, we performed a comprehensive and comparative phenotyping screening to identify phenotypic differences and similarities between the eight founder strains. In total, more than 300 parameters including allergy, behavior, cardiovascular, clinical blood chemistry, dysmorphology, bone and cartilage, energy metabolism, eye and vision, immunology, lung function, neurology, nociception, and pathology were analyzed; in most traits from sixteen females and sixteen males. We identified over 270 parameters that were significantly different between strains. This s...
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