This paper introduces a virtual laboratory to design prosthetic socket, which integrates a 3D CAD module, named Socket Modelling Assistant (SMA), specifically developed to create the socket digital model, and a CAE system to analyze the stump-socket interaction. Software tool, named Virtual Socket Lab (VSL), is part of a knowledge-based framework to design lower limb prosthesis centered on digital models of the patient or of his/her anatomical districts. The focus of this paper is on the definition of an automatic simulation procedure to study the stump-socket interaction and validate socket design. We first introduce the new design framework and main features of VSL. Then, we present a state of art on FE models adopted for residual lower-l...