Aged hematopoietic stem cells (HSCs) undergo biased lineage priming and differentiation toward production of myeloid cells. A comprehensive understanding of gene regulatory mechanisms causing HSC aging is needed to devise new strategies to sustainably improve immune function in aged individuals. Here, a focused short hairpin RNA screen of epigenetic factors reveals that the histone acetyltransferase Kat6b regulates myeloid cell production from hematopoietic progenitor cells. Within the stem and progenitor cell compartment, Kat6b is highly expressed in long-term (LT)-HSCs and is significantly decreased with aging at the transcript and protein levels. Knockdown of Kat6b in young LT-HSCs causes skewed production of myeloid cells at the expense...
We surveyed 16 published and unpublished data sets to determine whether a consistent pattern of tran...
Aging is associated with impairments in hematopoietic stem cell (HSC) function and an increased risk...
Many elderly people suffer from hematological diseases known to be highly age-dependent. Hematopoiet...
As lifespan is increasing globally, there is a critical need to identify strategies to extend health...
As hematopoietic stem cells (HSCs) age, they experience a multitude of changes that affect their epi...
Summary: Long-term hematopoietic stem cells (LT-HSCs) maintain hematopoietic output throughout an an...
The blood is composed of many different cell types that through tightly regulated mechanisms are der...
Age-related defects in stem cells can limit proper tissue maintenance and hence contribute to a shor...
To investigate the cell-intrinsic aging mechanisms that erode the function of somatic stem cells dur...
SummaryTo investigate the cell-intrinsic aging mechanisms that erode the function of somatic stem ce...
Hematopoietic stem cells (HSCs) are unique in their ability to self-renew and differentiate into all...
Aging hematopoietic stem cells (HSCs) exhibit defective lineage specification that is thought to be ...
Long-term hematopoietic stem cells (LT-HSCs) maintain hematopoietic output throughout an animal’s li...
Aging causes profound effects on the hematopoietic stem cell (HSC) pool, including an altered output...
The late stages of life, in most species including humans, are associated with a decline in the over...
We surveyed 16 published and unpublished data sets to determine whether a consistent pattern of tran...
Aging is associated with impairments in hematopoietic stem cell (HSC) function and an increased risk...
Many elderly people suffer from hematological diseases known to be highly age-dependent. Hematopoiet...
As lifespan is increasing globally, there is a critical need to identify strategies to extend health...
As hematopoietic stem cells (HSCs) age, they experience a multitude of changes that affect their epi...
Summary: Long-term hematopoietic stem cells (LT-HSCs) maintain hematopoietic output throughout an an...
The blood is composed of many different cell types that through tightly regulated mechanisms are der...
Age-related defects in stem cells can limit proper tissue maintenance and hence contribute to a shor...
To investigate the cell-intrinsic aging mechanisms that erode the function of somatic stem cells dur...
SummaryTo investigate the cell-intrinsic aging mechanisms that erode the function of somatic stem ce...
Hematopoietic stem cells (HSCs) are unique in their ability to self-renew and differentiate into all...
Aging hematopoietic stem cells (HSCs) exhibit defective lineage specification that is thought to be ...
Long-term hematopoietic stem cells (LT-HSCs) maintain hematopoietic output throughout an animal’s li...
Aging causes profound effects on the hematopoietic stem cell (HSC) pool, including an altered output...
The late stages of life, in most species including humans, are associated with a decline in the over...
We surveyed 16 published and unpublished data sets to determine whether a consistent pattern of tran...
Aging is associated with impairments in hematopoietic stem cell (HSC) function and an increased risk...
Many elderly people suffer from hematological diseases known to be highly age-dependent. Hematopoiet...