The structural integrity of buildings and infrastructures can be affected by either environmental conditions or unforeseen external actions. In order to efficiently detect damage, intended as an irreversible degradation of the structural stiffness, many identification algorithms have been proposed in the literature. Nevertheless, a crucial aspect to accurately estimate and locate such damage pertains to the configuration of the deployed structural health monitoring (SHM) system. In addressing this goal, a framework is here proposed for the optimal design of sensor networks, in terms of number, type and spatial deployment of the sensors. The rationale of the method is to simultaneously maximize the information associated with the measurement...