Rocking isolation of structures is evolving as an alternative design concept in earthquake engineering. The present paper investigates the seismic performance of an actual overpass bridge of the Attiki Odos motorway (Athens, Greece), employing two different concepts of rocking isolation: (a) rocking of the piers on the foundation (rocking piers); and (b) rocking of the pier and foundation assembly (rocking footings) on the soil. The examined bridge is an asymmetric 5-span system having a continuous deck and founded on surface foundations on a deep clay layer. The seismic performance of the two rocking-isolated bridges is comparatively assessed to the existing bridge, which is conventionally designed according to current seismic design codes...