Some molecular mechanisms of calcium phosphate metabolism in diabetes mellitus

We chose to study polymorphisms of vitamin D receptor gene (VDR), parathyroid hormone gene (PTH) and CASR gene whose protein products significantly affect calcium phosphate metabolism and are implicated in the pathogenesis of diabetes, which may also involve kidney damage. The aim of this study was to find out whether the VDR, PTH and CASR polymorphisms are associated with the risk of developing diabetes mellitus and its renal complications. The frequencies of alleles and genotypes were studied in the groups of diabetic patients a with and without kidney complications using either TaqMan probes or PCR-RFLP. Comparison of patients with diabetic nephropathy (DN) and healthy subjects identified statistically significant difference for the FokI polymorphism in VDR gene (P