The partial purification and characterization of a soluble activator of the cation transport adenosinetriphosophatase in bovine caudate nucleus

To many investigators, these observations suggested the existence of a molecular “pump” mechanism responsible for the maintenance of the ionic gradients. Extensive research over the last twenty years has resulted in the assignment of this role to the magnesium-dependent, sodium- and potassium-stimulated adenosine triphosphatase, first reported by Skou in 1957. This membrane-bound enzyme is the subject of the research presented in this thesis