Design, Synthesis, and In Vitro Binding Studies of Novel Peptides for HER2 Targeting Based on Knob-Socket Model

Overexpression of Human Epidermal Growth Factor Receptor 2 (HER2) protein is found in about 30% of breast cancers. HER2 has been considered as a target for receptor-mediated drug delivery system and antibodies for cancer treatment. Pertuzumab is an antibody that inhibits cell proliferation and differentiation by binding to the extracellular domain of HER2 and has been successfully used in the treatment of breast cancer. Compared to antibodies, peptides that selectively recognize tumor cells have advantages in solubility, stability, immunogenicity and cost