IN VITRO BINDING SPECIFICITY AND UPTAKE OF A NOVEL PEPTIDE FOR HER2 TARGETING

Human Epidermal Growth Factor Receptor 2 (HER2) is a cell surface receptor tyrosine kinase and plays a role in the signal pathways leading to cell proliferation and differentiation. To create a novel peptide that specifically binds to HER2, we previously designed a peptide molecule (HER2-PEP) that consists of two peptide chains based on the binding interactions between Pertuzumab and HER2. The in vitro binding specificity and uptake of HER2-PEP in HER2 over-expressed and non-expressed cells are reported in this presentation