Add to ORKGProperly designed trans-2-aminocyclohexanols possess a negative allosteric cooperativity and can serve as powerful conformational pH-triggers. Their protonation leads to a conformational flip due to a strong intramolecular hydrogen bond. This \u27impulse\u27 is mechanically transmitted by the cycle to induce a conformational change of a remote site, thus altering its properties. Variation of NR2 groups allows a tuning of the conformational equilibrium, which was studied by NMR. These triggers were used in pH-sensitive lipid vesicles for drug and gene delivery
We suggested recently a novel approach to making lipid amphiphiles and their colloids pH-sensitive: ...
Recently we described a novel strategy to render pH-sensitive lipid amphiphiles and their colloids: ...
We suggested recently a novel type of pH-sensitive delivery system, fliposomes , which contain tran...
Properly designed trans-2-aminocyclohexanols possess a negative allosteric cooperativity and can ser...
The cyclohexane-based conformationally controlled molecular switches provide a new and promising app...
The cyclohexane-based conformationally controlled molecular switches provide a new and promising app...
We developed a novel strategy to render liposomes pH-sensitive: a protonation-induced conformational...
Trans-2-Aminocyclohexanol (TACH) is a promising model for pH-triggerable molecular switches with a v...
Amino-cyclohexanol derivatives have been successful models for pH-triggered conformational switches....
Protonation-induced conformational change of lipid tails is reported as a novel strategy to render p...
Acid-sensitive liposome has drawn much interest as drug and gene carriers that release payloads spec...
In the past, aminocyclohexanol rings have been successfully utilized as pH-triggered molecular switc...
The conformationally controlled molecular switches provide a new and promising approach to substance...
We suggested recently a novel approach to making lipid amphiphiles and their colloids pH-sensitive: ...
Recently we described a novel strategy to render pH-sensitive lipid amphiphiles and their colloids: ...
We suggested recently a novel type of pH-sensitive delivery system, fliposomes , which contain tran...
Properly designed trans-2-aminocyclohexanols possess a negative allosteric cooperativity and can ser...
The cyclohexane-based conformationally controlled molecular switches provide a new and promising app...
The cyclohexane-based conformationally controlled molecular switches provide a new and promising app...
We developed a novel strategy to render liposomes pH-sensitive: a protonation-induced conformational...
Trans-2-Aminocyclohexanol (TACH) is a promising model for pH-triggerable molecular switches with a v...
Amino-cyclohexanol derivatives have been successful models for pH-triggered conformational switches....
Protonation-induced conformational change of lipid tails is reported as a novel strategy to render p...
Acid-sensitive liposome has drawn much interest as drug and gene carriers that release payloads spec...
In the past, aminocyclohexanol rings have been successfully utilized as pH-triggered molecular switc...
The conformationally controlled molecular switches provide a new and promising approach to substance...
We suggested recently a novel approach to making lipid amphiphiles and their colloids pH-sensitive: ...
Recently we described a novel strategy to render pH-sensitive lipid amphiphiles and their colloids: ...
We suggested recently a novel type of pH-sensitive delivery system, fliposomes , which contain tran...