Add to ORKGSince the decrease of pH is involved in many pathological and physiological pathways, it serves as an attractive stimulus to trigger the release of a drug/gene delivery system. We report our recent approaches to the design of pH-sensitive and yet biocompatible lipids and liposomes, including lipids with an acid-labile ortho-ester linker and lipids with the trans-2-aminocyclohexanol moiety as a conformational switch of lipid tails
The traditional anticancer drugs are distributed in vivo through systemic blood circulation with a v...
Acid-sensitive liposomes are used as nano-sized vesicles for targeted drug delivery to tumors and in...
AbstractpH-sensitive liposomes are designed to specifically triggered release the loaded drugs in re...
Since the decrease of pH is involved in many pathological and physiological pathways, it serves as a...
Since the decrease of pH is involved in many pathological and physiological pathways, it serves as a...
We developed a novel strategy to render liposomes pH-sensitive: a protonation-induced conformational...
In an effort to develop pH-sensitive lipoplexes for efficient gene delivery, we report three novel c...
Purpose. To characterize the ability of a novel pH-sensitive lipid to trigger the release of PEG-gra...
Acid-sensitive liposome has drawn much interest as drug and gene carriers that release payloads spec...
Context: Cationic lipoplexes are less toxic than viral gene vectors and more convenient to prepare b...
The synthesis and drug and gene delivery applications of four acid-labile, vinyl ether containing li...
International audienceLipid-based delivery systems are an established technology with considerable c...
Strategies used to enhance liposome-mediated drug delivery in vivo include the enhancement of stabil...
Endosome is a major barrier to efficient gene transfection by synthetic vectors because if the vecto...
We suggested recently a novel approach to making lipid amphiphiles and their colloids pH-sensitive: ...
The traditional anticancer drugs are distributed in vivo through systemic blood circulation with a v...
Acid-sensitive liposomes are used as nano-sized vesicles for targeted drug delivery to tumors and in...
AbstractpH-sensitive liposomes are designed to specifically triggered release the loaded drugs in re...
Since the decrease of pH is involved in many pathological and physiological pathways, it serves as a...
Since the decrease of pH is involved in many pathological and physiological pathways, it serves as a...
We developed a novel strategy to render liposomes pH-sensitive: a protonation-induced conformational...
In an effort to develop pH-sensitive lipoplexes for efficient gene delivery, we report three novel c...
Purpose. To characterize the ability of a novel pH-sensitive lipid to trigger the release of PEG-gra...
Acid-sensitive liposome has drawn much interest as drug and gene carriers that release payloads spec...
Context: Cationic lipoplexes are less toxic than viral gene vectors and more convenient to prepare b...
The synthesis and drug and gene delivery applications of four acid-labile, vinyl ether containing li...
International audienceLipid-based delivery systems are an established technology with considerable c...
Strategies used to enhance liposome-mediated drug delivery in vivo include the enhancement of stabil...
Endosome is a major barrier to efficient gene transfection by synthetic vectors because if the vecto...
We suggested recently a novel approach to making lipid amphiphiles and their colloids pH-sensitive: ...
The traditional anticancer drugs are distributed in vivo through systemic blood circulation with a v...
Acid-sensitive liposomes are used as nano-sized vesicles for targeted drug delivery to tumors and in...
AbstractpH-sensitive liposomes are designed to specifically triggered release the loaded drugs in re...