Add to ORKGWe suggested recently a novel approach to making lipid amphiphiles and their colloids pH-sensitive: a protonation-induced conformational switch of the built-in trans-2-aminocyclohexanol moiety. In liposomes, this ring flip loosens packing of the attached lipid tails, leading to contents leakage. Here we report our latest studies on the pH-sensitivity of PEG-grafted liposomes containing various trans-2-aminocyclohexanol-based lipids in their membranes. These liposomes are stable at pH 7.4 and yet release their content in a few seconds in a slightly acidic medium. The triggering pH value depends on the structure of amino-group
Purpose. To characterize the ability of a novel pH-sensitive lipid to trigger the release of PEG-gra...
Properly designed trans-2-aminocyclohexanols possess a negative allosteric cooperativity and can ser...
New developments are presented in the design of stimuli-responsive liposomes for targeted delivery v...
We suggested recently a novel approach to making lipid amphiphiles and their colloids pH-sensitive: ...
Recently we described a novel strategy to render pH-sensitive lipid amphiphiles and their colloids: ...
We developed a novel strategy to render liposomes pH-sensitive: a protonation-induced conformational...
A new type of pH-sensitive liposomes (fliposomes) was designed based on the amphiphiles that are abl...
Protonation-induced conformational change of lipid tails is reported as a novel strategy to render p...
Incorporation of a pH-sensitive conformational switch into a lipid structure enables a drastic confo...
Incorporation of a pH-sensitive conformational switch into a lipid structure enables a drastic confo...
We suggested recently a novel type of pH-sensitive delivery system, fliposomes , which contain tran...
Acid-sensitive liposome has drawn much interest as drug and gene carriers that release payloads spec...
A new type of pH-sensitive liposome (fliposomes) was designed based on the amphiphiles that are able...
Acid-sensitive liposomes are used as nano-sized vesicles for targeted drug delivery to tumors and in...
Purpose. To characterize the ability of a novel pH-sensitive lipid to trigger the release of PEG-gra...
Properly designed trans-2-aminocyclohexanols possess a negative allosteric cooperativity and can ser...
New developments are presented in the design of stimuli-responsive liposomes for targeted delivery v...
We suggested recently a novel approach to making lipid amphiphiles and their colloids pH-sensitive: ...
Recently we described a novel strategy to render pH-sensitive lipid amphiphiles and their colloids: ...
We developed a novel strategy to render liposomes pH-sensitive: a protonation-induced conformational...
A new type of pH-sensitive liposomes (fliposomes) was designed based on the amphiphiles that are abl...
Protonation-induced conformational change of lipid tails is reported as a novel strategy to render p...
Incorporation of a pH-sensitive conformational switch into a lipid structure enables a drastic confo...
Incorporation of a pH-sensitive conformational switch into a lipid structure enables a drastic confo...
We suggested recently a novel type of pH-sensitive delivery system, fliposomes , which contain tran...
Acid-sensitive liposome has drawn much interest as drug and gene carriers that release payloads spec...
A new type of pH-sensitive liposome (fliposomes) was designed based on the amphiphiles that are able...
Acid-sensitive liposomes are used as nano-sized vesicles for targeted drug delivery to tumors and in...
Purpose. To characterize the ability of a novel pH-sensitive lipid to trigger the release of PEG-gra...
Properly designed trans-2-aminocyclohexanols possess a negative allosteric cooperativity and can ser...
New developments are presented in the design of stimuli-responsive liposomes for targeted delivery v...