Development of Karplus Equations for 1,6-linked Disaccharides

Oligosaccharides are biochemically very important and are associated with a multitude of processes central to disease and are equally important to the human body’s response to such disease. Structural diversity because of constitution and configuration is greater than in any other category of biomacromolecules. An additional dimension to this “sugar code” is the glycan’s conformational flexibility. The glycosidic bond geometry in glycans describes an important part of the overall oligosaccharide conformation