An investigation of acute effects at various doses of malathion on glucose homeostasis and insulin resistance in rat liver, pancreas and serum

Objective. This study investigates acute effects of various doses of Malathion on glucose homeostasis and insulin resistance in rat. Methods. Rats were randomly divided into four groups of 6 animals each. Corn oil was given orally to Group 1. Group 2, Group 3, and Group 4 received malathion dissolved in corn oil via oral administration at the doses of 100, 200 and 400 mg/kg, respectively. 24 hours later the rats were sacrificed. Results. Acute administration of Malathion led to a decrease in serum butryl cholinesterase (BChE) levels at all doses tested. It also caused a significant increase in serum advanced glycation end products (AGEs), insulin, and TNF-α levels at all doses. Moreover, Malathion administration raised the liver ALT, AST and LDH, TNF-α, and glycogen levels in a dose dependent manner. It also led to a remarkable increase in pancreatic insulin levels at all doses. Conclusions. Acute administrations of Malathion affect glucose homeostasis in a dose dependent manner through its effects on the liver, serum, and pancreas