Beobachtungsstudie zur Bedeutung des ionisierten Magnesiums bei chronischer Niereninsuffizienz

Objective: The objective of this monocentric, prospective, non-interventional study was to measure the blood concentration of ionized magnesium in a cohort of patients with chronic kidney disease, not in need of dialysis, and to examine its relation to GFR, serum magnesium concentration and other relevant CKD parameters such as sclerostin, FGF23 and iPTH. Thus, it should be determined if the concentration of ionized magnesium might be clinically relevant in CKD. Furthermore, a formula was supposed to be generated intended to allow calculation of ionized magnesium and hence be able to supercede laboratory analyses. Methods: A blood sample was taken from inpatients with diagnosed CKD admitted to Nephrology and Internal Medicine at the University Hospital, Aachen, given informed consent. The concentration of ionized magnesium was assessed via BGA. The samples were centrifuged, with plasma and serum separated, and stored at -80°C. An external lab assessed additional parameters which were entered into a database together with the latest blood count and patient history. Results and conclusions: The examination of a predominantly male cohort of 93 patients with CKD stages II-V has validated the knowledge of certain pathophysiological metabolic processes in CKD / CKD-MBD. No statistically relevant correlations between Mg2+ and other study parameters were found. A formula for the calculation of ionized magnesium from serum magnesium and albumin was successfully generated and could serve as a reasonable alternative to laboratory analyses in the future