A supramolecular approach to the examination of the structures of some anticancer organoamidoplatinum(II) complexes

A range of supramolecular interactions revealed on assessment of crystal packing of the previously reported organoamidoplatinum(II) complexes, [Pt{(p-BrC6F4)NCH2CH2NEt2}(py)Cl], 1; [Pt{(p-HC6F4)NCH2CH2NEt2}(py)Cl], 2; [Pt{(C6F5)NCH2CH2NEt2}(py)I], 3; [Pt{(p-HC6F4)NCH2CH2NMe2}Cl(py)], 4; [Pt{(C6F5)NCH2CH2NMe2}Cl0.4I0.6(py)], 5 is examined. These interactions frequently include the axial positions above and below the coordination planes. Agostic interactions, inter- and intra-molecular H-bonding and other supramolecular interactions of all compounds were explored for a better understanding of solid state structural properties. This propensity to form a range of supramolecular interactions may assist in docking the drugs to DNA prior to coordination of DNA to these compounds