Lactic acid and fatigue in working sheep

[Extract] In a previous study (1) it was suggested from data on the concentration of circulating plasma lactic acid that fatigue in the working buffalo was probably caused by the accumulation of lactic acid in the muscles of the limbs of the animal. The suggestion was largely speculative as no examination of the flux of lactic acid into and out of, or its accumulation in the limb muscles was undertaken. This study, using sheep as the rumninant model was therefore conducted to examine the flux of lactic acid across the working hind-limb muscles