Autoreactive CD8 T cells play a central role in the destruction of pancreatic islet β-cells that leads to type 1 diabetes, yet the key features of this immune-mediated process remain poorly defined. In this study, we combined high-definition polychromatic flow cytometry with ultrasensitive peptide–human leukocyte antigen class I tetramer staining to quantify and characterize β-cell–specific CD8 T cell populations in patients with recent-onset type 1 diabetes and healthy control subjects. Remarkably, we found that β-cell–specific CD8 T cell frequencies in peripheral blood were similar between subject groups. In contrast to healthy control subjects, however, patients with newly diagnosed type 1 diabetes displayed hallmarks of antigen-driven e...
OBJECTIVE—Both the early steps and the high recurrence of autoimmunity once the disease is establish...
In type 1 diabetes, cytotoxic CD8+ T cells with specificity for β cell autoantigens are found in the...
International audienceOBJECTIVE Both the early steps and the high recurrence of autoimmunity once th...
Autoreactive CD8 T cells play a central role in the destruction of pancreatic islet β-cells that lea...
Autoreactive CD8 T cells play a central role in the destruction of pancreatic islet β-cells that lea...
Autoreactive CD8 T cells play a central role in the destruction of pancreatic islet β-cells that lea...
Autoreactive CD8 T cells play a central role in the destruction of pancreatic islet β-cells that lea...
Autoreactive CD8 T cells play a central role in the destruction of pancreatic islet β-cells that lea...
\u3cp\u3eAuto-reactive CD8 T-cells play an important role in the destruction of pancreatic β-cells r...
Auto-reactive CD8 T-cells play an important role in the destruction of pancreatic β-cells resulting ...
Auto-reactive CD8 T-cells play an important role in the destruction of pancreatic β-cells resulting ...
Auto-reactive CD8 T-cells play an important role in the destruction of pancreatic β-cells resulting ...
Auto-reactive CD8 T-cells play an important role in the destruction of pancreatic β-cells resulting...
Auto-reactive CD8 T-cells play an important role in the destruction of pancreatic β-cells resulting...
Abstract In type 1 diabetes (T1D), autoreactive cytotoxic CD8⁺ T cells are implicated in the destru...
OBJECTIVE—Both the early steps and the high recurrence of autoimmunity once the disease is establish...
In type 1 diabetes, cytotoxic CD8+ T cells with specificity for β cell autoantigens are found in the...
International audienceOBJECTIVE Both the early steps and the high recurrence of autoimmunity once th...
Autoreactive CD8 T cells play a central role in the destruction of pancreatic islet β-cells that lea...
Autoreactive CD8 T cells play a central role in the destruction of pancreatic islet β-cells that lea...
Autoreactive CD8 T cells play a central role in the destruction of pancreatic islet β-cells that lea...
Autoreactive CD8 T cells play a central role in the destruction of pancreatic islet β-cells that lea...
Autoreactive CD8 T cells play a central role in the destruction of pancreatic islet β-cells that lea...
\u3cp\u3eAuto-reactive CD8 T-cells play an important role in the destruction of pancreatic β-cells r...
Auto-reactive CD8 T-cells play an important role in the destruction of pancreatic β-cells resulting ...
Auto-reactive CD8 T-cells play an important role in the destruction of pancreatic β-cells resulting ...
Auto-reactive CD8 T-cells play an important role in the destruction of pancreatic β-cells resulting ...
Auto-reactive CD8 T-cells play an important role in the destruction of pancreatic β-cells resulting...
Auto-reactive CD8 T-cells play an important role in the destruction of pancreatic β-cells resulting...
Abstract In type 1 diabetes (T1D), autoreactive cytotoxic CD8⁺ T cells are implicated in the destru...
OBJECTIVE—Both the early steps and the high recurrence of autoimmunity once the disease is establish...
In type 1 diabetes, cytotoxic CD8+ T cells with specificity for β cell autoantigens are found in the...
International audienceOBJECTIVE Both the early steps and the high recurrence of autoimmunity once th...