Role of alanine racemase mutations in Mycobacterium tuberculosis D-cycloserine resistance
- Nakatani, Yoshio
- Opel-Reading, Helen K
- Merker, Matthias
- Machado, Diana
- Andres, Sönke
- Kumar, S Siva
- Moradigaravand, Danesh
- Coll, Francesc
- Perdigão, João
- Portugal, Isabel
- Schön, Thomas
- Nair, Dina
- Devi, K R Uma
- Kohl, Thomas A
- Beckert, Patrick
- Clark, Taane G
- Maphalala, Gugu
- Khumalo, Derrick
- Diel, Roland
- Klaos, Kadri
- Aung, Htin Lin
- Cook, Gregory M
- Parkhill, Julian
- Peacock, Sharon J
- Swaminathan, Soumya
- Viveiros, Miguel
- Niemann, Stefan
- Krause, Kurt L
- Köser, Claudio U
Publication date
December 2017
DOI Publisher
American Society for Microbiology Journal
Antimicrobial Agents and ChemotherapyAbstract
Copyright © 2017 Nakatani et al.A screening of more than 1,500 drug-resistant strains of Mycobacterium tuberculosis revealed evolutionary patterns characteristic of positive selection for three alanine racemase (Alr) mutations. We investigated these mutations using molecular modeling, in vitro MIC testing, as well as direct measurements of enzymatic activity, which demonstrated that these mutations likely confer resistance to d-cycloserinepublishersversionpublishersversionpublishe
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