Add to ORKGCONTEXT: The efficacy of antidepressant drug treatment in depression is unsatisfactory; 1 in 3 patients does not fully recover even after several treatment trials. Genetic factors and clinical characteristics contribute to the failure of a favorable treatment outcome. OBJECTIVE: To identify genetic and clinical determinants of antidepressant drug treatment outcome in depression. DESIGN: Genomewide pharmacogenetic association study with 2 independent replication samples. SETTING: We performed a genomewide association study in patients from the Munich Antidepressant Response Signature (MARS) project and in pooled DNA from an independent German replication sample. A set of 328 single-nucleotide polymorphisms highly related to outcome ...
OBJECTIVE: The purpose of this study was to identify genetic variants underlying the considerable in...
Antidepressants are often only moderately successful in decreasing the severity of depressive sympto...
Genome-wide association studies have generally failed to identify polymorphisms associated with anti...
CONTEXT: The efficacy of antidepressant drug treatment in depression is unsatisfactory; 1 in 3 patie...
[[abstract]]BACKGROUND: Antidepressants are a first-line treatment for depression. However, only a t...
Background: Antidepressants are a first-line treatment for depression. However, only a third of indi...
BACKGROUND: Genomewide association studies (GWASs) on antidepressant efficacy have yielded modest re...
Background: It has been suggested that outcomes of antidepressant treatment for major depressive dis...
Objective: Indirect evidence suggests that common genetic variation contributes to individual differ...
Objective: Indirect evidence suggests that common genetic variation contributes to individual differ...
Background: It has been suggested that outcomes of antidepressant treatment for major depressive dis...
Background It has been suggested that outcomes of antidepressant treatment for major depressive d...
Genome-wide association studies (GWAS) have failed to replicate common genetic variants associated w...
[[abstract]]Background: Antidepressants are considered one of the first-line intervention for major ...
Genome-wide association studies have generally failed to identify polymorphisms associated with anti...
OBJECTIVE: The purpose of this study was to identify genetic variants underlying the considerable in...
Antidepressants are often only moderately successful in decreasing the severity of depressive sympto...
Genome-wide association studies have generally failed to identify polymorphisms associated with anti...
CONTEXT: The efficacy of antidepressant drug treatment in depression is unsatisfactory; 1 in 3 patie...
[[abstract]]BACKGROUND: Antidepressants are a first-line treatment for depression. However, only a t...
Background: Antidepressants are a first-line treatment for depression. However, only a third of indi...
BACKGROUND: Genomewide association studies (GWASs) on antidepressant efficacy have yielded modest re...
Background: It has been suggested that outcomes of antidepressant treatment for major depressive dis...
Objective: Indirect evidence suggests that common genetic variation contributes to individual differ...
Objective: Indirect evidence suggests that common genetic variation contributes to individual differ...
Background: It has been suggested that outcomes of antidepressant treatment for major depressive dis...
Background It has been suggested that outcomes of antidepressant treatment for major depressive d...
Genome-wide association studies (GWAS) have failed to replicate common genetic variants associated w...
[[abstract]]Background: Antidepressants are considered one of the first-line intervention for major ...
Genome-wide association studies have generally failed to identify polymorphisms associated with anti...
OBJECTIVE: The purpose of this study was to identify genetic variants underlying the considerable in...
Antidepressants are often only moderately successful in decreasing the severity of depressive sympto...
Genome-wide association studies have generally failed to identify polymorphisms associated with anti...