Asymmetrische Dihydroxylierung (AD) und asymmetrische Aminohydroxylierung (AA) mit immobilisierten Alkaloiden

The Asymmetric Dihydroxylation (AD) and Asymmetric Aminohydroxylation (AA) of olefins introduced by Sharpless represent efficient methods for the preparation of diols respectively vicinal aminoalcohols. Within this thesis the attachment of different ligand types (pyrimidine-, diphenylpyrazinopyridazine- and anthraquinonestructure) on soluble (PEG) as well as insoluble (silica gel) supports could be optimised, so that the resulting products were obtained with high enantiomeric excesses. Most of the ee values were comparable to those which are achievable with the original not polymer supported Sharpless system. Furthermore the enlarged ligands showed an easy recycling ability either by selective precipitation or simple filtration. The recovered ligands could be used in consecutive catalyses without any significant loss of activity or enantioselectivity