This Ph. D. work is divided into two main projects. The first project is focused on the asymmetric synthesis of a very important class of natural products: lignans. Thirteen different lignans in high diastereo- and enantioselectivity have been synthesized. In the second project, a highly efficient asymmetric synthesis of a-(heteroaryl)alkylamines, based on nucleophilic 1,2-addition of heteroarenyllithium species to SAMP-/RAMP-hydrazones, has been developed. Moreover the novel methodology was successfully applied to the synthesis of biologically interesting compounds such as a-aminoacids and b-aminosulfones
The asymmetric allylation under the assistance of catalytic amounts of 3,3′-bis(2,4,6-triisopropylp...
This thesis centers on the asymmetric synthesis of polycyclic amines, focussing on three distinct cl...
The asymmetric allylation under the assistance of catalytic amounts of 3,3′-Bis(2,4,6-triisopropylph...
Lignans are a wide spread class of natural compounds which mainly occur in plants as secondary plant...
Nowadays, the stereoselective synthesis of naturally occurring compounds showing biological activity...
The asymmetric synthesis of the new lignan cubebin dimethyl ether was accomplished in eight steps wi...
Finland has a long history of utilizing wood as fuel, construction material and for paper production...
Addition of dithianes, derived from alkyl- and aryl-aldehydes, to (5R)-menthyloxy-2[5H]-furanone fol...
Two conceptually different approaches to the asymmetric synthesis of amines and amine derivatives vi...
The focus of this thesis work is the asymmetric synthesis of N,O-protected 1,3-aminoalcohols using S...
Optically active α,α-disubstituted α-amino acids represent a privileged structural motif present in ...
A general and efficient method is described for the asymmetric synthesis of a variety of lignans. 5-...
Addition of dithianes, derived from alkyl- and aryl-aldehydes, to (5R)-menthyloxy-2[5H]-furanone fol...
The synthesis of a new class of auxiliary based chiral synthons, γ-alkoxy-2(5H)-furanones, is descri...
A general and efficient method is described for the asymmetric synthesis of a variety of lignans. 5-...
The asymmetric allylation under the assistance of catalytic amounts of 3,3′-bis(2,4,6-triisopropylp...
This thesis centers on the asymmetric synthesis of polycyclic amines, focussing on three distinct cl...
The asymmetric allylation under the assistance of catalytic amounts of 3,3′-Bis(2,4,6-triisopropylph...
Lignans are a wide spread class of natural compounds which mainly occur in plants as secondary plant...
Nowadays, the stereoselective synthesis of naturally occurring compounds showing biological activity...
The asymmetric synthesis of the new lignan cubebin dimethyl ether was accomplished in eight steps wi...
Finland has a long history of utilizing wood as fuel, construction material and for paper production...
Addition of dithianes, derived from alkyl- and aryl-aldehydes, to (5R)-menthyloxy-2[5H]-furanone fol...
Two conceptually different approaches to the asymmetric synthesis of amines and amine derivatives vi...
The focus of this thesis work is the asymmetric synthesis of N,O-protected 1,3-aminoalcohols using S...
Optically active α,α-disubstituted α-amino acids represent a privileged structural motif present in ...
A general and efficient method is described for the asymmetric synthesis of a variety of lignans. 5-...
Addition of dithianes, derived from alkyl- and aryl-aldehydes, to (5R)-menthyloxy-2[5H]-furanone fol...
The synthesis of a new class of auxiliary based chiral synthons, γ-alkoxy-2(5H)-furanones, is descri...
A general and efficient method is described for the asymmetric synthesis of a variety of lignans. 5-...
The asymmetric allylation under the assistance of catalytic amounts of 3,3′-bis(2,4,6-triisopropylp...
This thesis centers on the asymmetric synthesis of polycyclic amines, focussing on three distinct cl...
The asymmetric allylation under the assistance of catalytic amounts of 3,3′-Bis(2,4,6-triisopropylph...