Monocytes are key players of the innate immune system and crucially modulate tissue inflammation after injury. Mammalian monocytes consist of two principle subsets that display different chemokine receptor expression levels. In humans, the classical monocyte CD14++CD16- subset expresses CCR2, CD64, CD62L and low levels of the fractalkine receptor CX3CR1, whereas the non-classical CD14lowCD16+ monocyte subset expresses high levels of CX3CR1 and lack CCR2. Their counterparts in mice are CCR2+Gr-1hi and CCR2-Gr-1low monocytes, respectively. Liver fibrosis is the consequence of chronic liver inflammation, which is characterized by the accumulation of extracellular matrix proteins such as collagen-I. Patients with liver fibrosis are at high ris...
Chronic liver diseases are characterized by a sustained inflammatory response in which chemokines an...
A hallmark of acute hepatic injury is the recruitment of neutrophils, monocytes and lymphocytes, inc...
Objective Acute-on-chronic liver failure (ACLF) is associated with dysfunctional circulating monocyt...
BACKGROUND: Monocyte-derived macrophages critically perpetuate inflammatory responses after liver in...
cells. We aimed at investigating the relevance of monocyte subpopulations for human liver fibrosis,...
<div><p>Background and Aims</p><p>Liver and systemic inflammatory factors influence monocyte phenoty...
Different etiologies such as drug toxicity, acute viral hepatitis B or acetaminophen poisoning can c...
Recent evidence suggests that hepatic dendritic cells (HDCs) contribute to the evolution of chronic ...
Chronic liver injury promotes hepatic inflammation, representing a prerequisite for organ fibrosis, ...
Chemokines and chemokine receptors contribute to the migration of hepatic stellate cells (HSCs) and ...
Multiple potentially harmful stimuli challenge the liver, the chief metabolic and detoxifying organ ...
Non-alcoholic fatty liver disease (NAFLD) is one major clinical burden in modern western societies. ...
Recruitment of CCR2(+)Ly6C(high) monocytes to sites of infection is essential for efficient clearanc...
Monocytes are a heterogeneous population of phagocytic cells that are generated in the bone marrow a...
Abstract The expression of chemokine receptor CX3CR1 is related to migration and signaling in cells ...
Chronic liver diseases are characterized by a sustained inflammatory response in which chemokines an...
A hallmark of acute hepatic injury is the recruitment of neutrophils, monocytes and lymphocytes, inc...
Objective Acute-on-chronic liver failure (ACLF) is associated with dysfunctional circulating monocyt...
BACKGROUND: Monocyte-derived macrophages critically perpetuate inflammatory responses after liver in...
cells. We aimed at investigating the relevance of monocyte subpopulations for human liver fibrosis,...
<div><p>Background and Aims</p><p>Liver and systemic inflammatory factors influence monocyte phenoty...
Different etiologies such as drug toxicity, acute viral hepatitis B or acetaminophen poisoning can c...
Recent evidence suggests that hepatic dendritic cells (HDCs) contribute to the evolution of chronic ...
Chronic liver injury promotes hepatic inflammation, representing a prerequisite for organ fibrosis, ...
Chemokines and chemokine receptors contribute to the migration of hepatic stellate cells (HSCs) and ...
Multiple potentially harmful stimuli challenge the liver, the chief metabolic and detoxifying organ ...
Non-alcoholic fatty liver disease (NAFLD) is one major clinical burden in modern western societies. ...
Recruitment of CCR2(+)Ly6C(high) monocytes to sites of infection is essential for efficient clearanc...
Monocytes are a heterogeneous population of phagocytic cells that are generated in the bone marrow a...
Abstract The expression of chemokine receptor CX3CR1 is related to migration and signaling in cells ...
Chronic liver diseases are characterized by a sustained inflammatory response in which chemokines an...
A hallmark of acute hepatic injury is the recruitment of neutrophils, monocytes and lymphocytes, inc...
Objective Acute-on-chronic liver failure (ACLF) is associated with dysfunctional circulating monocyt...