This treatise presents in detail a novel proposal that the tissue-type molecules are so varied and notoriously hard to match for purposes such as transplantation precisely because their purpose is to prevent matching, or more exactly duplication by invaders. This places the tissue-type molecules at the heart of the mechanisms that control and specifically turn off the immune system. The treatise presents the theory in detail, introduces ideas on how it may operate and the evidence that such a mechanism exists. The application of the idea to most fields of immunology is then discussed
For many decades, cellular immunologists have relied on the expression of various cell surface molec...
Historically, immunology emerged as a biomedical science, concerned with host defense and production...
The cellular immune system functions in large part to recognize and destroy foreign pathogens. This ...
The MHC-based suppression theory (MBS) was first proposed by the author as a system for T cell contr...
The immune system has evolved the capacity to react specifically with a very large number of foreign...
International audienceImmune system provides the mechanisms for attacking foreign invaders, eliminat...
The MHC controls specificity, to ensure that appropriate immune responses are mounted to invading pa...
The T-cell branch of the immune system can respond to a virtu-ally infinite variety of antigens, in ...
A great paradox in cellular immunology is how T cell allorecognition exists at high frequencies (up ...
B and T lymphocytes of the immune system employ a highly effective diversity-generating machinery to...
The ability of T lymphocytes (T cells) to recognize and attack foreign invaders while leaving health...
International audienceThe number of different major histocompatibility (MHC) molecules expressed per...
textabstractThe failure of successful exchange of tissues and organs between individuals of the same...
Organ transplantation offers hope to a variety of patients with terminal functioning organs and tiss...
The major histocompatibility complex (MHC) is famous for containing the most polymorphic loci in the...
For many decades, cellular immunologists have relied on the expression of various cell surface molec...
Historically, immunology emerged as a biomedical science, concerned with host defense and production...
The cellular immune system functions in large part to recognize and destroy foreign pathogens. This ...
The MHC-based suppression theory (MBS) was first proposed by the author as a system for T cell contr...
The immune system has evolved the capacity to react specifically with a very large number of foreign...
International audienceImmune system provides the mechanisms for attacking foreign invaders, eliminat...
The MHC controls specificity, to ensure that appropriate immune responses are mounted to invading pa...
The T-cell branch of the immune system can respond to a virtu-ally infinite variety of antigens, in ...
A great paradox in cellular immunology is how T cell allorecognition exists at high frequencies (up ...
B and T lymphocytes of the immune system employ a highly effective diversity-generating machinery to...
The ability of T lymphocytes (T cells) to recognize and attack foreign invaders while leaving health...
International audienceThe number of different major histocompatibility (MHC) molecules expressed per...
textabstractThe failure of successful exchange of tissues and organs between individuals of the same...
Organ transplantation offers hope to a variety of patients with terminal functioning organs and tiss...
The major histocompatibility complex (MHC) is famous for containing the most polymorphic loci in the...
For many decades, cellular immunologists have relied on the expression of various cell surface molec...
Historically, immunology emerged as a biomedical science, concerned with host defense and production...
The cellular immune system functions in large part to recognize and destroy foreign pathogens. This ...