Mendelian randomisation analysis strongly implicates adiposity with risk of developing colorectal cancer
- Jarvis, D
- Mitchell, JS
- Law, PJ
- Palin, K
- Tuupanen, S
- Gylfe, A
- Hänninen, UA
- Cajuso, T
- Tanskanen, T
- Kondelin, J
- Kaasinen, E
- Sarin, AP
- Kaprio, J
- Eriksson, JG
- Rissanen, H
- Knekt, P
- Pukkala, E
- Jousilahti, P
- Salomaa, V
- Ripatti, S
- Palotie, A
- Järvinen, H
- Renkonen-Sinisalo, L
- Lepistö, A
- Böhm, J
- Meklin, JP
- Al-Tassan, NA
- Palles, C
- Martin, L
- Barclay, E
- Farrington, SM
- Timofeeva, MN
- Meyer, BF
- Wakil, SM
- Campbell, H
- Smith, CG
- Idziaszczyk, S
- Maughan, TS
- Kaplan, R
- Kerr, R
- Kerr, D
- Buchanan, DD
- Win, AK
- Hopper, JL
- Jenkins, MA
- Lindor, NM
- Newcomb, PA
- Gallinger, S
- Conti, D
- Schumacher, F
- Casey, G
- Taipale, J
- Aaltonen, LA
- Cheadle, JP
- Dunlop, MG
- Tomlinson, IP
- Houlston, RS
DOIAbstract
Observational studies have associated adiposity with an increased risk of colorectal cancer (CRC). However, such studies do not establish a causal relationship. To minimise bias from confounding we performed a Mendelian randomisation (MR) analysis to examine the relationship between adiposity and CRC.We used SNPs associated with adult body mass index (BMI), waist-hip ratio (WHR), childhood obesity and birth weight as instrumental variables in a MR analysis of 9254 CRC cases and 18 386 controls.In the MR analysis, the odds ratios (ORs) of CRC risk per unit increase in BMI, WHR and childhood obesity were 1.23 (95% CI: 1.02-1.49, P=0.033), 1.59 (95% CI: 1.08-2.34, P=0.019) and 1.07 (95% CI: 1.03-1.13, P=0.018), respectively. There was no evide...
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