A crucial step in the development of the vertebrate visual system is the branching of retinal ganglion cell (RGC) axons within their target, the superior colliculus/tectum. A major player in this process is the neurotrophin brain-derived neurotrophic factor (BDNF). However, the molecular basis for the signaling pathways mediating BDNF action is less well understood. As BDNF exerts some of its functions by controlling the expression of microRNAs (miRNAs), we investigated whether miRNAs are also involved in BDNF-mediated retinal axon branching. Here, we demonstrate that the expression pattern of miRNA-132 in the retina is consistent with its involvement in this process, and that BDNF induces the upregulation of miRNA-132 in retinal cultures. ...
Background MicroRNAs (miRNAs) are short non-coding RNAs predicted to regulate one third of protein c...
BACKGROUND: MicroRNAs (miRNAs) are short non-coding RNAs predicted to regulate one third of protein ...
<p><strong>Background</strong> Brain-derived neurotrophic factor (BDNF) plays a crucial role in the...
Retinal axon specification and growth are critically sensitive to the dosage of numerous signaling m...
Retinal axon specification and growth are critically sensitive to the dosage of numerous signaling m...
During embryonic development, axons extend over long distances to establish functional connections. ...
Background/Aims: Retinal Müller cells could be induced to differentiate into retinal ganglion cells ...
Connectivity and function of neuronal circuitry require the correct specification and growth of axon...
Retinal axon specification and growth are critically sensitive to the dosage of numerous sig-naling ...
miRNA are short non-coding RNA responsible for the knockdown of proteins through their targeting and...
During embryonic retinal development, six types of retinal neurons are generated from multipotent pr...
The highly complex nervous system is built upon an intricate network of neurons. In order to make a ...
During the development of the nervous system, axons grow and generate a complex network of interconn...
During development axons encounter a variety of choice points where they have to make appropriate pa...
Selva, EricaYoo, SoonmoonThe precise regulation of selective mRNA transport to its final destination...
Background MicroRNAs (miRNAs) are short non-coding RNAs predicted to regulate one third of protein c...
BACKGROUND: MicroRNAs (miRNAs) are short non-coding RNAs predicted to regulate one third of protein ...
<p><strong>Background</strong> Brain-derived neurotrophic factor (BDNF) plays a crucial role in the...
Retinal axon specification and growth are critically sensitive to the dosage of numerous signaling m...
Retinal axon specification and growth are critically sensitive to the dosage of numerous signaling m...
During embryonic development, axons extend over long distances to establish functional connections. ...
Background/Aims: Retinal Müller cells could be induced to differentiate into retinal ganglion cells ...
Connectivity and function of neuronal circuitry require the correct specification and growth of axon...
Retinal axon specification and growth are critically sensitive to the dosage of numerous sig-naling ...
miRNA are short non-coding RNA responsible for the knockdown of proteins through their targeting and...
During embryonic retinal development, six types of retinal neurons are generated from multipotent pr...
The highly complex nervous system is built upon an intricate network of neurons. In order to make a ...
During the development of the nervous system, axons grow and generate a complex network of interconn...
During development axons encounter a variety of choice points where they have to make appropriate pa...
Selva, EricaYoo, SoonmoonThe precise regulation of selective mRNA transport to its final destination...
Background MicroRNAs (miRNAs) are short non-coding RNAs predicted to regulate one third of protein c...
BACKGROUND: MicroRNAs (miRNAs) are short non-coding RNAs predicted to regulate one third of protein ...
<p><strong>Background</strong> Brain-derived neurotrophic factor (BDNF) plays a crucial role in the...