The heart develops from a simple left-right (L-R) symmetrical tube. Through a complex process of looping and remodelling, it becomes a highly L-R asymmetrical organ with distinct asymmetries in both morphology and function. Abnormal cardiac L-R patterning can result in a spectrum of defects that include, dextrocardia (a malposition of the heart to the right), isomerism of the atria (both atria being morphologically right-sided or left-sided), abnormal ventricular topology (e.g. the morphological left ventricle being dextral to the morphological right ventricle) or mirror-image topology (associated with situs inversus). Intermediate forms include abnormalities such as situs ambiguus and heterotaxia. L-R patterning abnormalities are typically...
Abstract Transcriptional differences between left and right cardiac chambers are revealed by an nlac...
Failure to properly establish the left–right (L/R) axis is a major cause of congenital heart defects...
Cardiovascular development is initiated soon after gastrulation as bilateral precardiac mesoderm is ...
The heart develops from a simple left-right (L-R) symmetrical tube. Through a complex process of loo...
Many aspects of heart development are determined by the left right axis and as a result several cong...
The heart is laterally asymmetric. Not only is it positioned on the left side of the body but the or...
AbstractCellular and molecular left–right differences that are present in the mesodermal heart field...
The heart is laterally asymmetric. Not only is it positioned on the left side of the body but the or...
Human beings are characterized by a left–right asymmetric arrangement of their internal organs...
The external features of the vertebrate body plan are bi-laterally symmetric. In contrast, many of t...
The heart is the first organ to break symmetry in the developing embryo and onset of dextral looping...
The invariant nature of body situs within and across vertebrate species implies that a highly conser...
Disruption of organ left-right (LR) asymmetry, or laterality, during embryo development can result i...
Over the past 10 years, key genes involved in specification of left-right laterality pathways in the...
Although vertebrates appear bilaterally symmetric on the outside, various internal organs, including...
Abstract Transcriptional differences between left and right cardiac chambers are revealed by an nlac...
Failure to properly establish the left–right (L/R) axis is a major cause of congenital heart defects...
Cardiovascular development is initiated soon after gastrulation as bilateral precardiac mesoderm is ...
The heart develops from a simple left-right (L-R) symmetrical tube. Through a complex process of loo...
Many aspects of heart development are determined by the left right axis and as a result several cong...
The heart is laterally asymmetric. Not only is it positioned on the left side of the body but the or...
AbstractCellular and molecular left–right differences that are present in the mesodermal heart field...
The heart is laterally asymmetric. Not only is it positioned on the left side of the body but the or...
Human beings are characterized by a left–right asymmetric arrangement of their internal organs...
The external features of the vertebrate body plan are bi-laterally symmetric. In contrast, many of t...
The heart is the first organ to break symmetry in the developing embryo and onset of dextral looping...
The invariant nature of body situs within and across vertebrate species implies that a highly conser...
Disruption of organ left-right (LR) asymmetry, or laterality, during embryo development can result i...
Over the past 10 years, key genes involved in specification of left-right laterality pathways in the...
Although vertebrates appear bilaterally symmetric on the outside, various internal organs, including...
Abstract Transcriptional differences between left and right cardiac chambers are revealed by an nlac...
Failure to properly establish the left–right (L/R) axis is a major cause of congenital heart defects...
Cardiovascular development is initiated soon after gastrulation as bilateral precardiac mesoderm is ...