During heart development the second heart field (SHF) provides progenitor cells for most cardiomyocytes and expresses the homeodomain factor Nkx2-5. We now show that feedback repression of Bmp2/Smad1 signaling by Nkx2-5 critically regulates SHF proliferation and outflow tract (OFT) morphology. In the cardiac fields of Nkx2-5 mutants, genes controlling cardiac specification (including Bmp2) and maintenance of the progenitor state were upregulated, leading initially to progenitor overspecification, but subsequently to failed SHF proliferation and OFT truncation. In Smad1 mutants, SHF proliferation and deployment to the OFT were increased, while Smad1 deletion in Nkx2-5 mutants rescued SHF proliferation and OFT development. In Nkx2-5 hypomorph...
AbstractHuman mutations in Nkx2-5 lead to progressive cardiomyopathy and conduction defects via unkn...
AbstractThe sinoatrial node (SAN), functionally known as the pacemaker, regulates the cardiac rhythm...
AbstractNeural crest cells (NCCs) are indispensable for the development of the cardiac outflow tract...
SummaryDuring heart development the second heart field (SHF) provides progenitor cells for most card...
AbstractIn the forming vertebrate heart, bone morphogenetic protein signaling induces expression of ...
AbstractNkx2.5/Csx and dHAND/Hand2 are conserved transcription factors that are coexpressed in the p...
Congenital heart defects can be caused by mutations in genes that guide cardiac lineage formation. H...
Congenital heart defects can be caused by mutations in genes that guide cardiac lineage formation. H...
Congenital heart defects can be caused by mutations in genes that guide cardiac lineage formation. H...
AbstractHuman mutations in Nkx2-5 lead to progressive cardiomyopathy and conduction defects via unkn...
Congenital heart defects can be caused by mutations in genes that guide cardiac lineage formation. H...
AbstractIn the forming vertebrate heart, bone morphogenetic protein signaling induces expression of ...
AbstractHeart formation in vertebrates and fruit flies requires signaling by bone morphogenetic prot...
AbstractThe cardiac homeobox gene Nkx2.5 plays a key and dosage-sensitive role in the differentiatio...
AbstractNeural crest cells (NCCs) are indispensable for the development of the cardiac outflow tract...
AbstractHuman mutations in Nkx2-5 lead to progressive cardiomyopathy and conduction defects via unkn...
AbstractThe sinoatrial node (SAN), functionally known as the pacemaker, regulates the cardiac rhythm...
AbstractNeural crest cells (NCCs) are indispensable for the development of the cardiac outflow tract...
SummaryDuring heart development the second heart field (SHF) provides progenitor cells for most card...
AbstractIn the forming vertebrate heart, bone morphogenetic protein signaling induces expression of ...
AbstractNkx2.5/Csx and dHAND/Hand2 are conserved transcription factors that are coexpressed in the p...
Congenital heart defects can be caused by mutations in genes that guide cardiac lineage formation. H...
Congenital heart defects can be caused by mutations in genes that guide cardiac lineage formation. H...
Congenital heart defects can be caused by mutations in genes that guide cardiac lineage formation. H...
AbstractHuman mutations in Nkx2-5 lead to progressive cardiomyopathy and conduction defects via unkn...
Congenital heart defects can be caused by mutations in genes that guide cardiac lineage formation. H...
AbstractIn the forming vertebrate heart, bone morphogenetic protein signaling induces expression of ...
AbstractHeart formation in vertebrates and fruit flies requires signaling by bone morphogenetic prot...
AbstractThe cardiac homeobox gene Nkx2.5 plays a key and dosage-sensitive role in the differentiatio...
AbstractNeural crest cells (NCCs) are indispensable for the development of the cardiac outflow tract...
AbstractHuman mutations in Nkx2-5 lead to progressive cardiomyopathy and conduction defects via unkn...
AbstractThe sinoatrial node (SAN), functionally known as the pacemaker, regulates the cardiac rhythm...
AbstractNeural crest cells (NCCs) are indispensable for the development of the cardiac outflow tract...