A full genome screen for autism with evidence for linkage to a region on chromosome 7q. International Molecular Genetic Study of Autism Consortium.
- Bailey, A
- Hervas, A
- Matthews, N
- Palferman, S
- Wallace, S
- Aubin, A
- Michelotti, J
- Wainhouse, C
- Papanikolaou, K
- Rutter, M
- Maestrini, E
- Marlow, A
- Weeks, DE
- Lamb, J
- Francks, C
- Kearsley, G
- Scudder, P
- Monaco, AP
- Baird, G
- Cox, A
- Cockerill, H
- Le Couteur, A
- Berney, T
- Cooper, H
- Kelly, T
- Green, J
- Whittaker, J
- Gilchrist, A
- Bolton, P
- Schönewald, A
- Daker, M
- Ogilvie, C
- Docherty, Z
- Deans, Z
- Bolton, B
- Packer, R
- Poustka, F
- Rühl, D
- Schmötzer, G
- Bölte, S
- Klauck, SM
- Spieler, A
- Poustka, A
- Van Engeland, H
- Kemner, C
- De Jonge, M
- Den Hartog, I
- Lord, C
- Cook, E
- Leventhal, B
- Volkmar, F
- Pauls, D
- Klin, A
- Smalley, S
- Fombonne, E
- Rogé, B
- Tauber, M
- Arti-Vartayan, E
- Fremolle-Kruck, J
- Pederson, L
- Haracopos, D
- Brondum-Nielsen, K
- Cotterill, R
DOIAbstract
Autism is characterized by impairments in reciprocal social interaction and communication, and restricted and sterotyped patterns of interests and activities. Developmental difficulties are apparent before 3 years of age and there is evidence for strong genetic influences most likely involving more than one susceptibility gene. A two-stage genome search for susceptibility loci in autism was performed on 87 affected sib pairs plus 12 non-sib affected relative-pairs, from a total of 99 families identified by an international consortium. Regions on six chromosomes (4, 7, 10, 16, 19 and 22) were identified which generated a multipoint maximum lod score (MLS) > 1. A region on chromosome 7q was the most significant with an MLS of 3.55 near marker...
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