Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior.
- Thorgeirsson, TE
- Gudbjartsson, DF
- Surakka, I
- Vink, JM
- Amin, N
- Geller, F
- Sulem, P
- Rafnar, T
- Esko, T
- Walter, S
- Gieger, C
- Rawal, R
- Mangino, M
- Prokopenko, I
- Mägi, R
- Keskitalo, K
- Gudjonsdottir, IH
- Gretarsdottir, S
- Stefansson, H
- Thompson, JR
- Aulchenko, YS
- Nelis, M
- Aben, KK
- den Heijer, M
- Dirksen, A
- Ashraf, H
- Soranzo, N
- Valdes, AM
- Steves, C
- Uitterlinden, AG
- Hofman, A
- Tönjes, A
- Kovacs, P
- Hottenga, JJ
- Willemsen, G
- Vogelzangs, N
- Döring, A
- Dahmen, N
- Nitz, B
- Pergadia, ML
- Saez, B
- De Diego, V
- Lezcano, V
- Garcia-Prats, MD
- Ripatti, S
- Perola, M
- Kettunen, J
- Hartikainen, AL
- Pouta, A
- Laitinen, J
- Isohanni, M
- Huei-Yi, S
- Allen, M
- Krestyaninova, M
- Hall, AS
- Jones, GT
- van Rij, AM
- Mueller, T
- Dieplinger, B
- Haltmayer, M
- Jonsson, S
- Matthiasson, SE
- Oskarsson, H
- Tyrfingsson, T
- Kiemeney, LA
- Mayordomo, JI
- Lindholt, JS
- Pedersen, JH
- Franklin, WA
- Wolf, H
- Montgomery, GW
- Heath, AC
- Martin, NG
- Madden, PA
- Giegling, I
- Rujescu, D
- Järvelin, MR
- Salomaa, V
- Stumvoll, M
- Spector, TD
- Wichmann, HE
- Metspalu, A
- Samani, NJ
- Penninx, BW
- Oostra, BA
- Boomsma, DI
- Tiemeier, H
- van Duijn, CM
- Kaprio, J
- Gulcher, JR
- McCarthy, MI
- Peltonen, L
- Thorsteinsdottir, U
- Stefansson, K
DOIAbstract
Smoking is a common risk factor for many diseases. We conducted genome-wide association meta-analyses for the number of cigarettes smoked per day (CPD) in smokers (n = 31,266) and smoking initiation (n = 46,481) using samples from the ENGAGE Consortium. In a second stage, we tested selected SNPs with in silico replication in the Tobacco and Genetics (TAG) and Glaxo Smith Kline (Ox-GSK) consortia cohorts (n = 45,691 smokers) and assessed some of those in a third sample of European ancestry (n = 9,040). Variants in three genomic regions associated with CPD (P < 5 x 10(-8)), including previously identified SNPs at 15q25 represented by rs1051730[A] (effect size = 0.80 CPD, P = 2.4 x 10(-69)), and SNPs at 19q13 and 8p11, represented by rs4105144...
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