Protective effect of HLA-B57 on HCV genotype 2 infection in a West African population.
- Chuang, WC
- Sarkodie, F
- Brown, CJ
- Owusu-Ofori, S
- Brown, J
- Li, C
- Navarrete, C
- Klenerman, P
- Allain, JP
DOIAbstract
Recovery from Hepatitis C virus (HCV) infection is considered infrequent (<20%) in western populations but reaches 50% in West Africa where genotype 2 infection is predominant. To investigate the role of cellular immune responses and host genetics in this phenomenon, samples from 104 Ghanaian blood donors reactive with anti-HCV assays were collected between 2000 and 2005. HCV antibody was confirmed by Western blot using genotype 2 recombinant core, E2 and NS3 proteins. Viral load and genotype were determined. Samples were stratified into 37 chronic, 35 recovered infections and 32 false positive. Eighty-one percentage of subjects with chronic infection (RNA positive) carried genotype 2 HCV. Cellular immune response was investigated in 35 fro...
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