Unprecedented regiocontrol using an aldolase I antibody.

Direct asymmetric aldol reactions at the less substituted carbon atom of unmodified unsymmetrical ketones are achieved in the presence of the commercially available aldolase I antibody 84G3 [Eq. (1)]. All the reactions proceeded with enantiomeric excesses greater than 94%. Both enantiomers are accessible by using either an aldol or a retro-aldol reaction