Deregulated over expression of FOXP1 protein in diffuse large B-cell lymphoma does not occur as a result of gene rearrangement.
- Barrans, SL
- Fenton, JA
- Ventura, R
- Smith, A
- Banham, AH
- Jack, AS
Publication date
June 2007
DOI Publisher
Ferrata Storti Foundation (Haematologica) Journal
HaematologicaAbstract
Strong uniform expression of FOXP1 protein occurs in a subgroup of non-germinal centre (GC) diffuse large B-cell lymphomas (DLBCL). We have investigated gene rearrangement as a potential mechanism for deregulated expression of FOXP1 however, using FISH FOXP1 translocations were not found in any case with over-expression of the protein
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