Spinal lamina I is a key element of the pain processing system which relays primary afferent input to supraspinal areas. However, little is known about how the signal is modulated by its intrinsic network including local-circuit neurones (LCNs) and much less numerous anterolateral tract projection neurones (PNs). Here, we used whole-cell patch clamp recordings in an isolated spinal cord preparation to examine properties of identified LCNs (n = 85) and PNs (n = 73) in their functionally preserved local networks. Forty LCNs showed spontaneous rhythmic firing (2-7 Hz) at zero current injection, which persisted in the presence of blockers of fast synaptic transmission. In the remaining cases, most LCNs and PNs fired tonically in response to dep...
Large projection neurons in lamina III of the rat spinal cord that express the neurokinin 1 receptor...
Abstract Background Pain-related (nociceptive) information is carried from the periphery to the dors...
AbstractLamina II contains a large number of interneurons involved in modulation and transmission of...
Spinal lamina I is a key element of the pain processing system which relays primary afferent input t...
Spinal lamina I is a key element of the pain processing system, which integrates primary afferent in...
Referred pain is a phenomenon of feeling pain at a site other than the site of the painful stimulus ...
The spinal dorsal horn is the first relay structure coding for pain transmission and modulation. Pre...
Networks of the dorsal horn of the spinal cord process nociceptive information from the periphery. U...
Lamina I spino-parabrachial neurons (SPNs) receive peripheral nociceptive input, process it and tran...
Referred pain is a phenomenon of feeling pain at a site other than the site of the painful stimulus ...
Despite being involved in a number of functions, such as nociception and locomotion, spinal lamina X...
SummaryPain information processing in the spinal cord has been postulated to rely on nociceptive tra...
Lamina II contains a large number of interneurons involved in modulation and transmission of somatos...
Neural circuitry of the spinal superficial dorsal horn (SDH) (laminae I and II) and its relationship...
Introduction It has been reported that inhibitory control at the superficial dorsal horn (SDH) can a...
Large projection neurons in lamina III of the rat spinal cord that express the neurokinin 1 receptor...
Abstract Background Pain-related (nociceptive) information is carried from the periphery to the dors...
AbstractLamina II contains a large number of interneurons involved in modulation and transmission of...
Spinal lamina I is a key element of the pain processing system which relays primary afferent input t...
Spinal lamina I is a key element of the pain processing system, which integrates primary afferent in...
Referred pain is a phenomenon of feeling pain at a site other than the site of the painful stimulus ...
The spinal dorsal horn is the first relay structure coding for pain transmission and modulation. Pre...
Networks of the dorsal horn of the spinal cord process nociceptive information from the periphery. U...
Lamina I spino-parabrachial neurons (SPNs) receive peripheral nociceptive input, process it and tran...
Referred pain is a phenomenon of feeling pain at a site other than the site of the painful stimulus ...
Despite being involved in a number of functions, such as nociception and locomotion, spinal lamina X...
SummaryPain information processing in the spinal cord has been postulated to rely on nociceptive tra...
Lamina II contains a large number of interneurons involved in modulation and transmission of somatos...
Neural circuitry of the spinal superficial dorsal horn (SDH) (laminae I and II) and its relationship...
Introduction It has been reported that inhibitory control at the superficial dorsal horn (SDH) can a...
Large projection neurons in lamina III of the rat spinal cord that express the neurokinin 1 receptor...
Abstract Background Pain-related (nociceptive) information is carried from the periphery to the dors...
AbstractLamina II contains a large number of interneurons involved in modulation and transmission of...