Multi-ethnic genome-wide association study for atrial fibrillation
- Roselli, C
- Chaffin, MD
- Weng, L-C
- Aeschbacher, S
- Ahlberg, G
- Albert, CM
- Almgren, P
- Alonso, A
- Anderson, CD
- Aragam, KG
- Arking, DE
- Barnard, J
- Bartz, TM
- Benjamin, EJ
- Bihlmeyer, NA
- Bis, JC
- Bloom, HL
- Boerwinkle, E
- Bottinger, EB
- Brody, JA
- Calkins, H
- Campbell, A
- Cappola, TP
- Carlquist, J
- Chasman, DI
- Chen, LY
- Chen, Y-DI
- Choi, E-K
- Choi, SH
- Christophersen, IE
- Chung, MK
- Cole, JW
- Conen, D
- Cook, J
- Crijns, HJ
- Cutler, MJ
- Damrauer, SM
- Daniels, BR
- Darbar, D
- Delgado, G
- Denny, JC
- Dichgans, M
- Dörr, M
- Dudink, EA
- Dudley, SC
- Esa, N
- Esko, T
- Eskola, M
- Fatkin, D
- Felix, SB
- Ford, I
- Franco, OH
- Geelhoed, B
- Grewal, RP
- Gudnason, V
- Guo, X
- Gupta, N
- Gustafsson, S
- Gutmann, R
- Hamsten, A
- Harris, TB
- Hayward, C
- Heckbert, SR
- Hernesniemi, J
- Hocking, LJ
- Hofman, A
- Horimoto, ARVR
- Huang, J
- Huang, PL
- Huffman, J
- Ingelsson, E
- Ipek, EG
- Ito, K
- Jimenez-Conde, J
- Johnson, R
- Jukema, JW
- Kääb, S
- Kähönen, M
- Kamatani, Y
- Kane, JP
- Kastrati, A
- Kathiresan, S
- Katschnig-Winter, P
- Kavousi, M
- Kessler, T
- Kietselaer, BL
- Kirchhof, P
- Kleber, ME
- Knight, S
- Krieger, JE
- Kubo, M
- Launer, LJ
- Laurikka, J
- Lehtimäki, T
- Leineweber, K
- Lemaitre, RN
- Li, M
- Lim, HE
- Lin, HJ
- Lin, H
- Lind, L
- Lindgren, CM
- Lokki, M-L
- London, B
- Loos, RJF
- Low, S-K
- Lu, Y
- Lyytikäinen, L-P
- Macfarlane, PW
- Magnusson, PK
- Mahajan, A
- Malik, R
- Mansur, AJ
- Marcus, GM
- Margolin, L
- Margulies, KB
- März, W
- McManus, DD
- Melander, O
- Mohanty, S
- Montgomery, JA
- Morley, MP
- Morris, AP
- Müller-Nurasyid, M
- Natale, A
- Nazarian, S
- Neumann, B
- Newton-Cheh, C
- Niemeijer, MN
- Nikus, K
- Nilsson, P
- Noordam, R
- Oellers, H
- Olesen, MS
- Orho-Melander, M
- Padmanabhan, S
- Pak, H-N
- Paré, G
- Pedersen, NL
- Pera, J
- Pereira, A
- Porteous, D
- Psaty, BM
- Pulit, SL
- Pullinger, CR
- Rader, DJ
- Refsgaard, L
- Ribasés, M
- Ridker, PM
- Rienstra, M
- Risch, L
- Roden, DM
- Rosand, J
- Rosenberg, MA
- Rost, N
- Rotter, JI
- Saba, S
- Sandhu, RK
- Schnabel, RB
- Schramm, K
- Schunkert, H
- Schurman, C
- Scott, SA
- Seppälä, I
- Shaffer, C
- Shah, S
- Shalaby, AA
- Shim, J
- Shoemaker, MB
- Siland, JE
- Sinisalo, J
- Sinner, MF
- Slowik, A
- Smith, AV
- Smith, BH
- Smith, JG
- Smith, JD
- Smith, NL
- Soliman, EZ
- Sotoodehnia, N
- Stricker, BH
- Sun, A
- Sun, H
- Svendsen, JH
- Tanaka, T
- Tanriverdi, K
- Taylor, KD
- Teder-Laving, M
- Teumer, A
- Thériault, S
- Trompet, S
- Tucker, NR
- Tveit, A
- Uitterlinden, AG
- Van Der Harst, P
- Van Gelder, IC
- Van Wagoner, DR
- Verweij, N
- Vlachopoulou, E
- Völker, U
- Wang, B
- Weeke, PE
- Weijs, B
- Weiss, R
- Weiss, S
- Wells, QS
- Wiggins, KL
- Wong, JA
- Woo, D
- Worrall, BB
- Yang, P-S
- Yao, J
- Yoneda, ZT
- Zeller, T
- Zeng, L
- Lubitz, SA
- Lunetta, KL
- Ellinor, PT
DOIAbstract
Atrial fibrillation (AF) affects more than 33 million individuals worldwide1 and has a complex heritability2. We conducted the largest meta-analysis of genome-wide association studies (GWAS) for AF to date, consisting of more than half a million individuals, including 65,446 with AF. In total, we identified 97 loci significantly associated with AF, including 67 that were novel in a combined-ancestry analysis, and 3 that were novel in a European-specific analysis. We sought to identify AF-associated genes at the GWAS loci by performing RNA-sequencing and expression quantitative trait locus analyses in 101 left atrial samples, the most relevant tissue for AF. We also performed transcriptome-wide analyses that identified 57 AF-associated genes...
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