A method is described to amplify the delivery of 111In to human breast cancer cells utilizing a novel human serum albumin-human EGF (HSA-hEGF) bioconjugate substituted preferentially in the HSA domain with multiple DTPA metal chelators for 111In. 111In-DTPA-HSA-hEGF exhibited a lower receptor-binding affinity than 111In-DTPA-hEGF but was rapidly and specifically bound, internalized and translocated to the nucleus in EGFR-positive MDA-MB-468 breast cancer cells. 111In-DTPA-HSA-hEGF was cytotoxic in vitro mainly through the emission of short-range Auger electrons and partially through the effects of the hEGF moiety to MDA-MB-468 cells overexpressing EGFR (1-2 x 10(6) receptors/cell) but not towards MCF-7 breast cancer cells with a 100-fold lo...
The epidermal growth factor receptor (EGFR) is overexpressed in more than 90% of pancreatic cancer (...
Several anti-cancer therapies target the epidermal growth factor receptor (EGFR). Radionuclide imagi...
UNLABELLED: Our goal was to design and manufacture a kit under good manufacturing practices (GMP) fo...
Our objective was to determine whether the internalization and nuclear translocation of human epider...
Purpose Radiolabeled antibodies and peptides hold promise for molecular radiotherapy but are often l...
Our objective was to compare 111In-labeled human epidermal growth factor (hEGF), a 53-amino acid pep...
Many anticancer therapies, including ionizing radiation (IR), cause cytotoxicity through generation ...
Many anticancer therapies, including ionizing radiation (IR), cause cytotoxicity through generation ...
grantor: University of TorontoThe overexpression of the epidermal growth factor receptor i...
Tumour targeted radiotherapy is an appealing approach for treatment of disseminated tumour cells. A ...
UNLABELLED: (111)In-DTPA-human epidermal growth factor ((111)In-DTPA-hEGF [DTPA is diethylenetriamin...
The successful use of targeted radionuclide therapy in the treatment of solid tumours may be limited...
INTRODUCTION: Our objective was to evaluate the effect of epidermal growth factor receptor(s) (EGFR)...
111In-DTPA–human epidermal growth factor (111In-DTPA-hEGF [DTPA is diethylenetriaminepentaacetic aci...
Expression of human epidermal growth factor receptor type 3 (HER3) in malignant tumors has been asso...
The epidermal growth factor receptor (EGFR) is overexpressed in more than 90% of pancreatic cancer (...
Several anti-cancer therapies target the epidermal growth factor receptor (EGFR). Radionuclide imagi...
UNLABELLED: Our goal was to design and manufacture a kit under good manufacturing practices (GMP) fo...
Our objective was to determine whether the internalization and nuclear translocation of human epider...
Purpose Radiolabeled antibodies and peptides hold promise for molecular radiotherapy but are often l...
Our objective was to compare 111In-labeled human epidermal growth factor (hEGF), a 53-amino acid pep...
Many anticancer therapies, including ionizing radiation (IR), cause cytotoxicity through generation ...
Many anticancer therapies, including ionizing radiation (IR), cause cytotoxicity through generation ...
grantor: University of TorontoThe overexpression of the epidermal growth factor receptor i...
Tumour targeted radiotherapy is an appealing approach for treatment of disseminated tumour cells. A ...
UNLABELLED: (111)In-DTPA-human epidermal growth factor ((111)In-DTPA-hEGF [DTPA is diethylenetriamin...
The successful use of targeted radionuclide therapy in the treatment of solid tumours may be limited...
INTRODUCTION: Our objective was to evaluate the effect of epidermal growth factor receptor(s) (EGFR)...
111In-DTPA–human epidermal growth factor (111In-DTPA-hEGF [DTPA is diethylenetriaminepentaacetic aci...
Expression of human epidermal growth factor receptor type 3 (HER3) in malignant tumors has been asso...
The epidermal growth factor receptor (EGFR) is overexpressed in more than 90% of pancreatic cancer (...
Several anti-cancer therapies target the epidermal growth factor receptor (EGFR). Radionuclide imagi...
UNLABELLED: Our goal was to design and manufacture a kit under good manufacturing practices (GMP) fo...