OBJECTIVE: It has been reported that both normal pituitary and pituitary tumours express PPAR-gamma, a nuclear hormone receptor, the expression being more abundant in pituitary tumours, and that this is the basis for the reported antiproliferative effects of the thiazolidinedione, rosiglitazone, in animal models. However, the mechanisms for the responsivity to rosiglitazone have remained unclear. DESIGN AND MEASUREMENTS: To investigate this further, 'real-time' PCR was used to assess PPAR-gamma mRNA expression, and Western blotting and immunohistochemistry to study its protein expression, in 46 human pituitary tumours and normal pituitary tissue. Cell proliferation of the GH3 pituitary cell line was assessed by [3H]-thymidine-incorporation ...
BACKGROUND/AIM: Despite combined therapy consisting of surgery, external X-ray, and medical therapy,...
of anti-tumour effects occurs only at suprapharmacological doses. In this study, we investigated the...
Objective: Rosiglitazone, a thiazolidinedione compound with peroxisome proliferator-activated recep-...
expression in pituitary tumours and the functional activity of the glitazones: evidence that any ant...
Summary: Rosiglitazone, a synthetic peroxisome proliferator-activated receptor γ (PPARγ) ligand, has...
NoPeroxisome proliferator-activated receptor gamma (PPARgamma), a member of the nuclear receptor sup...
Abstract: The occurrence of peroxisome proliferator-activated receptors gamma (PPARγ) was investigat...
The occurrence of peroxisome proliferator-activated receptors gamma (PPARγ) was investigate...
Peroxisome proliferator-activated receptor alpha (PPARα) has been involved in the regulation of soma...
Abstract OBJECTIVE: Expression of peroxisome proliferator-activated receptor (PPAR)gamma in norm...
Peroxisome proliferator-activated receptor gamma (PPAR gamma) is a nuclear receptor involved in such...
Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a nutrient-sensing transcription fa...
Objective: Rosiglitazone, a thiazolidinedione compound with peroxisome proliferator-activated recept...
BACKGROUND: Although PPARgamma antagonists have shown considerable pre-clinical efficacy, recent stu...
Background/Aim: Despite combined therapy consisting of surgery, external X-ray, and medical therapy,...
BACKGROUND/AIM: Despite combined therapy consisting of surgery, external X-ray, and medical therapy,...
of anti-tumour effects occurs only at suprapharmacological doses. In this study, we investigated the...
Objective: Rosiglitazone, a thiazolidinedione compound with peroxisome proliferator-activated recep-...
expression in pituitary tumours and the functional activity of the glitazones: evidence that any ant...
Summary: Rosiglitazone, a synthetic peroxisome proliferator-activated receptor γ (PPARγ) ligand, has...
NoPeroxisome proliferator-activated receptor gamma (PPARgamma), a member of the nuclear receptor sup...
Abstract: The occurrence of peroxisome proliferator-activated receptors gamma (PPARγ) was investigat...
The occurrence of peroxisome proliferator-activated receptors gamma (PPARγ) was investigate...
Peroxisome proliferator-activated receptor alpha (PPARα) has been involved in the regulation of soma...
Abstract OBJECTIVE: Expression of peroxisome proliferator-activated receptor (PPAR)gamma in norm...
Peroxisome proliferator-activated receptor gamma (PPAR gamma) is a nuclear receptor involved in such...
Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a nutrient-sensing transcription fa...
Objective: Rosiglitazone, a thiazolidinedione compound with peroxisome proliferator-activated recept...
BACKGROUND: Although PPARgamma antagonists have shown considerable pre-clinical efficacy, recent stu...
Background/Aim: Despite combined therapy consisting of surgery, external X-ray, and medical therapy,...
BACKGROUND/AIM: Despite combined therapy consisting of surgery, external X-ray, and medical therapy,...
of anti-tumour effects occurs only at suprapharmacological doses. In this study, we investigated the...
Objective: Rosiglitazone, a thiazolidinedione compound with peroxisome proliferator-activated recep-...